S Engeli, J Böhnke, M Feldpausch, K Gorzelniak, J … - Diabetes, 2005 - Am Diabetes Assoc Obesity is the main risk factor for the development of type 2 diabetes. Activation of the central
endocannabinoid system increases food intake and promotes weight gain. Blockade of the cannabinoid
type 1 (CB-1) receptor reduces body weight in animals by central and peripheral actions; ... Cited by 217 - Related articles - BL Direct - All 12 versions
- ►endojournals.org I Matias, MP Gonthier, P Orlando, V Martiadis, L … - Journal of Clinical …, 2006 - Endocrine Soc Context: Cannabinoid CB 1 receptor blockade decreases weight and hyperinsulinemia in obese
animals and humans in a way greatly independent from food intake. ... Objective: The objective
of this study was to investigate the regulation and function of the endocannabinoid system ... Cited by 174 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org M Blüher, S Engeli, N Klöting, J Berndt, M Fasshauer, S … - Diabetes, 2006 - Am Diabetes Assoc The endocannabinoid system has been suspected to contribute to the association of visceral
fat accumulation with metabolic diseases. We determined whether circulating endocannabinoids
are related to visceral adipose tissue mass in lean, subcutaneous obese, and visceral ... Cited by 132 - Related articles - BL Direct - All 8 versions
- ►nih.gov D Osei-Hyiaman, M DePetrillo, P Pacher, J … - Journal of Clinical …, 2005 - Am Soc Clin Investig Endogenous cannabinoids acting at CB 1 receptors stimulate appetite, and CB 1 antagonists
show promise in the treatment of obesity. CB 1 –/– mice are resistant to diet-induced obesity
even though their caloric intake is similar to that of wild-type mice, suggesting that ... Cited by 398 - Related articles - All 13 versions
- ►aspetjournals.org M Bensaid, M Gary-Bobo, A Esclangon, JP Maffrand, … - Molecular pharmacology, 2003 - ASPET This study investigates the effects of SR141716, a selective CB 1 receptor antagonist that reduces
food intake and body weight of rodents, on Acrp30 mRNA expression in adipose tissue.
Acrp30, a plasma protein exclusively expressed and secreted by adipose tissue, has ... Cited by 367 - Related articles - BL Direct - All 5 versions
JC Sipe, J Waalen, A Gerber, E Beutler - International Journal of Obesity, 2005 - nature.com The brain endogenous cannabinoid system modulates reward and craving pathways and consequently
may affect body weight. A naturally occurring missense polymorphism in the gene encoding
fatty acid amide hydrolase (FAAH), the primary enzyme for inactivation of ... Cited by 112 - Related articles - All 4 versions
YL Liu, IP Connoley, CA Wilson, MJ Stock - International Journal of Obesity, 2004 - nature.com To investigate the effect of SR141716, a selective CB1 receptor antagonist, on energy expenditure
and on glucose uptake in isolated soleus muscle of Lep ob /Lep ob mice. ... Female Lep ob
/Lep ob mice (8–10 weeks old) were treated with SR141716 (10 mg/kg, ip once daily) or ... Cited by 172 - Related articles - All 4 versions
- ►endojournals.org U Pagotto, G Marsicano, D Cota, B Lutz, R Pasquali - Endocrine reviews, 2006 - Endocrine Soc During the last few years, the endocannabinoid system has emerged as a highly relevant topic
in the scientific community. Many different regulatory actions have been attributed to
endocannabinoids, and their involvement in several pathophysiological conditions is ... Cited by 251 - Related articles - BL Direct - All 14 versions
P Juan-Picó, E Fuentes, F Javier Bermudez-Silva, F … - Cell Calcium, 2006 - Elsevier Insulin is the main hormone involved in the regulation of glycaemia, its impaired secretion is
a hallmark of type I and type II diabetic individuals. Additionally, insulin is involved in lipogenesis
and weight gain, provoking an anorexigenic action. The endocannabinoid system ... Cited by 88 - Related articles - All 4 versions
