CW Lin, F Yan, S Shimamura, S Barg, SL … - Diabetes, 2005 - Am Diabetes Assoc ATP-sensitive K + channels (K ATP channels) of pancreatic β-cells play key
roles in glucose-stimulated insulin secretion by linking metabolic signals to
cell excitability. Membrane phosphoinositides, in particular ... Cited by 16 - Related articles - BL Direct - All 6 versions
CW Lin, YW Lin, FF Yan, J Casey, M Kochhar, … - Diabetes, 2006 - Am Diabetes Assoc Heterozygous missense mutations in the pore-forming subunit Kir6.2 of
ATP-sensitive K + channels (K ATP channels) have recently been shown to cause
permanent neonatal diabetes mellitus (PNDM). Functional studies ... Cited by 12 - Related articles - BL Direct - All 5 versions
K Yang, K Fang, L Fromondi, KW Chan - FEBS letters, 2005 - Elsevier The pancreatic ATP-sensitive potassium channels comprise two subunits: SUR1 and
Kir6.2. Two SUR1 mutations, A116P and V187D, reduce channel activity causing
persistent hyperinsulinemic hypoglycemia of infancy. We investigated ... Cited by 10 - Related articles - All 4 versions
M Suchi, CM MacMullen, PS Thornton, NS … - Modern pathology, 2005 - nature.com Congenital hyperinsulinism is a rare pancreatic endocrine cell disorder that has
been categorized histologically into diffuse and focal forms. In focal
hyperinsulinism, the pancreas contains a focus of endocrine cell ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►jbc.org FF Yan, J Casey, SL Shyng - Journal of Biological Chemistry, 2006 - ASBMB ATP-sensitive potassium (K ATP ) channels mediate glucose-induced insulin
secretion by coupling metabolic signals to -cell membrane potential and the
secretory machinery. Reduced K ATP channel expression caused by mutations ... Cited by 13 - Related articles - All 6 versions
- ►endojournals.org MJ Henwood, A Kelly, C MacMullen, P Bhatia, … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Congenital hyperinsulinism (HI) is most commonly caused by recessive mutations
of the pancreatic ß-cell ATP-sensitive potassium channel (K ATP ), encoded by
two genes on chromosome 11p, SUR1 and Kir6.2. The two mutations that have ... Cited by 31 - Related articles - All 4 versions
- ►diabetesjournals.org FF Yan, YW Lin, C MacMullen, A Ganguly, CA … - Diabetes, 2007 - Am Diabetes Assoc Congenital hyperinsulinism (CHI) is a disease characterized by persistent
insulin secretion despite severe hypoglycemia. Mutations in the pancreatic
ATP-sensitive K + (K ATP ) channel proteins sulfonylurea receptor 1 (SUR1) ... Cited by 9 - Related articles - BL Direct - All 5 versions
A Crane, L Aguilar-Bryan - Journal of Biological Chemistry, 2004 - ASBMB ATP-sensitive K + , or K ATP , channels are comprised of K IR 6.x and
sulfonylurea receptor (SUR) subunits that assemble as octamers, (K IR /SUR) 4 .
The assembly pathway is unknown. Pulse-labeling studies show that when K IR ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►jbc.org F Yan, CW Lin, E Weisiger, EA Cartier, G … - Journal of Biological Chemistry, 2004 - ASBMB The pancreatic ATP-sensitive potassium (K ATP ) channel, a complex of four
sulfonylurea receptor 1 (SUR1) and four potassium channel Kir6.2 subunits,
regulates insulin secretion by linking metabolic changes to -cell membrane ... Cited by 35 - Related articles - BL Direct - All 5 versions
