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Scholar Results 1 - 10 of about 101 related to Noguchi: BETA2/NeuroD protein can be transduced into cells due to an arginine-and lysine-rich.... (0.12 sec) 

BETA2/NeuroD protein can be transduced into cells due to an arginine-and lysine-rich …

- diabetesjournals.org
H Noguchi, S Bonner-Weir, FY Wei, M … - Diabetes, 2005 - Am Diabetes Assoc
BETA2/NeuroD, a basic helix-loop-helix transcription factor, is a key regulator
of pancreatic islet morphogenesis and insulin gene transcription. Here we report
for the first time that the BETA2/NeuroD protein can permeate several ...
Cited by 34 - Related articles - BL Direct - All 6 versions

Mechanism of PDX-1 protein transduction


H Noguchi, M Matsushita, S Matsumoto, YF Lu … - Biochemical and Biophysical Research …, 2005 - Elsevier
PDX-1 plays a central role in differentiation of insulin-producing cells. We
previously reported that exogenous PDX-1 protein can permeate cells and induce
insulin gene expression in progenitor cells. These data suggest a strategy ...
Cited by 25 - Related articles - All 6 versions

PDX-1 protein containing its own antennapedia-like protein transduction domain can …


H Noguchi, H Kaneto, GC Weir, S Bonner- … - Diabetes, 2003 - Am Diabetes Assoc
The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1
/IPF1, a homeodomain-containing transcription factor, plays a central role in
regulating pancreatic development and insulin gene transcription. ...
Cited by 104 - Related articles - BL Direct - All 6 versions

PDX-1 protein is internalized by lipid raft-dependent macropinocytosis


H Noguchi, S Matsumoto, T Okitsu, Y Iwanaga, … - Cell Transplantation, 2005 - ingentaconnect.com
PDX-1 plays a central role in regulating insulin gene transcription and
differentiation of insulin-producing cells. It was previously reported that, due
to its own Antennapedia-like protein transduction domain (PTD), exogenous ...
Cited by 21 - Related articles - BL Direct - All 3 versions

Protein transduction technology offers a novel therapeutic approach for diabetes


H Noguchi, S Matsumoto - Journal of Hepato-Biliary-Pancreatic Surgery, 2006 - Springer
1 Diabetes Research Institute Kyoto, Kyoto, Japan 2 Research Fellow of the Japan
Society for the Promotion of Science (SPD), Kyoto, Japan 3 Department of
Transplantation and Immunology, Kyoto University Graduate School of ...
Cited by 13 - Related articles - BL Direct - All 4 versions

TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine …

- diabetesjournals.org
J Domínguez-Bendala, D Klein, M Ribeiro, C … - Diabetes, 2005 - Am Diabetes Assoc
Stem cell technologies hold great potential for the treatment of type 1
diabetes, provided that functional transplantable ß-cells can be selectively
generated in an efficient manner. Such a process should recapitulate, at ...
Cited by 43 - Related articles - All 5 versions

Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation …


H Noguchi, Y Nakai, S Matsumoto, M … - American Journal of Transplantation, 2005 - ccmjournal.org
Although application of the Edmonton protocol has markedly improved outcomes for
pancreatic islet transplantation, the insulin independence rate after islet
transplantation from one donor pancreas has proven to remain low. During ...
Cited by 37 - Related articles - All 7 versions

A novel type of PTD, common helix–loop–helix motif, could efficiently mediate protein …


J Chen, G Li, J Lu, L Chen, Y Huang, H Wu, J … - Biochemical and Biophysical Research …, 2006 - Elsevier
Protein transduction domains (PTDs), such as HIV TAT PTD, have been widely used
as delivery tools into living cells. Here we reported for the first time that
the helix–loop–helix (HLH) domain of basic helix–loop–helix (bHLH) ...
Cited by 12 - Related articles - All 5 versions

[PDF] Protein transduction technology: a novel therapeutic perspective


H Noguchi, S Matsumoto - Acta Medica Okayama, 2006 - lib.okayama-u.ac.jp
The direct intracellular delivery of proteins has, until recently, been
difficult to achieve, due primar- ily to the bioavailability barrier of the
plasma membrane. During the past 15 years, a variety of peptides called ...
Cited by 49 - Related articles - View as HTML - BL Direct - All 8 versions

A new cell-permeable peptide allows successful allogeneic islet transplantation in mice


H Noguchi, M Matsushita, T Okitsu, A … - Nature medicine, 2004 - nature.com
1 Department of Physiology and Transplant and Surgical Oncology, Okayama
University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho,
Okayama, 700-8558 Japan. ... 2 Department of Gastroenterological Surgery, ...
Cited by 94 - Related articles - BL Direct - All 4 versions


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