- ►shouxi.net AK Busch, E Gurisik, DV Cordery, M Sudlow, … - Diabetes, 2005 - Am Diabetes Assoc Increased availability of fatty acids causes cell death and dysfunction in
β-cell lines, isolated islets, and animal models of diabetes. From the MIN6
β-cell line, we selected two subpools that are resistant to ... Cited by 40 - Related articles - BL Direct - All 5 versions
JH Moffitt, BA Fielding, R Evershed, R Berstan … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Long-term exposure of beta cells to lipids,
particularly saturated fatty acids in vitro, results in cellular dysfunction and
apoptosis (lipotoxicity); this could contribute to obesity-related ... Cited by 36 - Related articles - BL Direct - All 3 versions
- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which
may contribute to the development of type 2 diabetes. The mechanisms involved in
FFA-induced cell death are not completely understood. Here we have ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►endojournals.org I Maestre, J Jordan, S Calvo, JA Reig, V Cena … - Endocrinology, 2003 - Endocrine Soc The potential toxic effects of high extracellular concentrations of fatty acids
were tested in ß(INS-1)-cells cultured in the absence of serum, a condition
known to alter cell survival in various systems. This may in part mimic the ... Cited by 82 - Related articles - BL Direct - All 8 versions
K Maedler, J Oberholzer, P Bucher, GA … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
monounsaturated fatty acids at different glucose concentrations on human ... Cited by 149 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JB Flowers, ME Rabaglia, KL Schueler, MT … - Diabetes, 2007 - Am Diabetes Assoc The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising new
target for obesity-related diabetes, as mice deficient in this enzyme are
resistant to diet- and leptin deficiency–induced obesity. The BTBR mouse ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►physiology.org E Lai, G Bikopoulos, MB Wheeler, M Rozakis- … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Chronic exposure to elevated saturated free fatty acid (FFA) levels has been
shown to induce endoplasmic reticulum (ER) stress that may contribute to
promoting pancreatic β-cell apoptosis. Here, we compared the effects of ... Cited by 19 - Related articles - BL Direct - All 3 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty
acids (FFAs) together with hyperglycemia are synergistic in causing islet
ß-cell damage because high glucose inhibits fat oxidation and consequently ... Cited by 173 - Related articles - BL Direct - All 5 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & ... Cited by 103 - Related articles - BL Direct - All 5 versions
