S Bacci, O Ludovico, S Prudente, YY Zhang, R Di … - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The
K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate
the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control ... Cited by 54 - Related articles - BL Direct - All 5 versions
N Abate, M Chandalia, P Satija, B Adams-Huet, SM … - Diabetes, 2005 - Am Diabetes Assoc Genetic susceptibility modulates the impact of obesity on risk for type 2 diabetes. The present
study evaluates the role of ENPP1 K121Q polymorphism in prediction of type 2 diabetes in three
populations that differ in susceptibility to diabetes and environmental exposure. The three ... Cited by 74 - Related articles - All 9 versions
- ►tokushima-u.ac.jp [PDF] P Keshavarz, H Inoue, Y Sakamoto, K Kunika, T … - Journal of Human …, 2006 - Springer Abstract Ecto-nucleotide pyrophosphatase/phosphodi- esterase 1 (ENPP1, also known as
PC-1) inhibits insulin signal transduction pathway(s). Previous studies have demonstrated the
K121Q variant of the ENPP1 gene to have a significant functional role in determining sus- ... Cited by 29 - Related articles - BL Direct - All 9 versions
- ►endojournals.org N Abate, L Carulli, A Cabo-Chan Jr, M … - Journal of Clinical …, 2003 - Endocrine Soc Genetic susceptibility may be responsible for high prevalence of insulin resistance in Asian
Indians. This study was carried out in samples of local Asian Indians and Caucasians to determine
whether plasma cell membrane glycoprotein (PC)-1 K121Q and insulin receptor ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►pubget.com [PDF] N Grarup, SA Urhammer, J Ek, A Albrechtsen, C … - Diabetologia, 2006 - Springer Page 1. ARTICLE Studies of the relationship between the ENPP1 K121Q
polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish
white subjects N. Grarup & SA Urhammer & J. Ek & A. Albrechtsen & ... Cited by 41 - Related articles - BL Direct - All 5 versions
BV Costanzo, V Trischitta, R Di Paola, D Spampinato, A … - Diabetes, 2001 - Am Diabetes Assoc When overexpressed, the membrane glycoprotein PC-1 may play a role in human insulin resistance
through the inhibition of insulin receptor (IR) autophosphorylation. A PC-1 variant (K 121 Q, with
lysine 121 replaced by glutamine) is also associated with whole-body insulin resistance ... Cited by 76 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org J Bochenski, G Placha, K Wanic, M Malecki, J Sieradzki … - Diabetes, 2006 - Am Diabetes Assoc The K121Q polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1
(ENPP1) is associated with type 2 diabetes and obesity. The possibility of other ENPP1 polymorphisms
influencing these phenotypes has received little attention. Our aim was to examine the ... Cited by 35 - Related articles - BL Direct - All 6 versions
D Meyre, N Bouatia-Naji, A Tounian, C Samson, … - Nature …, 2005 - pubmedcentral.nih.gov We identified a childhood obesity locus on chromosome 6q16.3-q24.2 1 that includes 2.4 Mb
common to eight genome scans for Type 2 diabetes (T2D) or obesity 1 - 8 . Analysis of the ENPP1
(PC-1) gene, a candidate for insulin resistance 9 , 10 in 6,147 subjects revealed ... Cited by 161 - Related articles - BL Direct - All 10 versions
N Matsuoka, A Patki, HK Tiwari, DB Allison, SB … - International Journal of …, 2005 - nature.com To test for association of the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1)
K121Q polymorphism with body mass index (BMI) and diabetes in a large sample of Caucasians
and African-Americans by selectively genotyping individuals at the extremes of the ... Cited by 40 - Related articles - BL Direct - All 4 versions
A Kubaszek, J Pihlajamäki, P Karhapää, I … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—The 121Q allele (genotypes K121Q and Q121Q) compared with the K121K genotype
was related to higher fasting insulin levels (group I: 69.6 ± 45.6 vs. 51.9 ± 28.4 pmol/l [mean ±
SD], P = 0.050; group II: 66.6 ± 38.8 vs. 53.8 ± 26.6 pmol/l, P = 0.009). In group I, subjects ... Cited by 44 - Related articles - BL Direct - All 5 versions
