- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the pancreatic
β-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion. When
K ATP channels open, β-cells hyperpolarize and insulin secretion is suppressed. The ... Cited by 43 - Related articles - BL Direct - All 5 versions
JC Koster, MA Permutt, CG Nichols - DIABETES, 2005 - Am Diabetes Assoc The ATP-sensitive K channel (K ATP channel) senses met- abolic changes in the pancreatic
-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion. When
K ATP channels open, -cells hyperpolarize and insulin secretion is suppressed. The ... Related articles
- ►diabetesjournals.org JC Koster, MS Remedi, C Dao, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The prediction that overactivity of the pancreatic ATP-sensitive K + channel (K ATP channel)
underlies reduced insulin secretion and causes a diabetic phenotype in humans has recently
been borne out by genetic studies implicating "activating" mutations in the Kir6.2 subunit ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►physiology.org H Huopio, SL Shyng, T Otonkoski, CG … - American Journal of …, 2002 - Am Physiological Soc ATP-sensitive potassium (K ATP ) channels are inhibited by intracellular ATP and activated by
ADP. Nutrient oxidation in -cells leads to a rise in [ATP]-to-[ADP] ratios, which in turn leads to
reduced K ATP channel activity, depolarization, voltage-dependent Ca 2+ channel ... Cited by 61 - Related articles - BL Direct - All 6 versions
- ►nih.gov P Proks, JF Antcliff, J Lippiat, AL Gloyn, … - Proceedings of the …, 2004 - National Acad Sciences Inwardly rectifying potassium channels (Kir channels) control cell membrane K + fluxes and electrical
signaling in diverse cell types. Heterozygous mutations in the human Kir6.2 gene (KCNJ11),
the pore-forming subunit of the ATP-sensitive (K ATP ) channel, cause permanent ... Cited by 115 - Related articles - All 11 versions
КД Николс, Д Костер, Д Энквечакул, Т Флагг - … : Журнал мембранной и …, 2006 - elibrary.ru В различных органах и тканях уникальной функцией АТР-чувствительных К+-каналов (К
АТР) являя-ется обеспечение взаимосвязи между метаболизмом клеток и их
возбудимостью. Например, в глад-комышечных клетках активации К АТР-каналов ... Related articles
AT Hattersley, FM Ashcroft - Diabetes, 2005 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) in response to metabolically generated
ATP or binding of sulfonylurea drugs stimulates insulin release from pancreatic β-cells. Heterozygous
gain-of-function mutations in the KCJN11 gene encoding the Kir6.2 subunit of this ... Cited by 138 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org EL Edghill, AL Gloyn, KM Gillespie, AP Lambert, NT … - Diabetes, 2004 - Am Diabetes Assoc We have recently shown that permanent neonatal diabetes can be caused by activating mutations
in KCNJ11 that encode the Kir6.2 subunit of the ß-cell ATP-sensitive K + channel. Some of these
patients were diagnosed after 3 months of age and presented with ketoacidosis and ... Cited by 25 - Related articles - BL Direct - All 4 versions
AL Gloyn, J Siddiqui, S Ellard - Human mutation, 2006 - interscience.wiley.com The beta-cell ATP-sensitive potassium channel is a key component of stimulus-secretion coupling
in the pancreatic beta-cell. The channel couples metabolism to membrane electrical events,
bringing about insulin secretion. Given the critical role of this channel in glucose ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►rupress.org D Enkvetchakul, CG Nichols - Journal of General Physiology, 2003 - jgp.rupress.org Based initially on their prominence in the squid giant axon, their useful pharmacology, and subsequently
on being the first cloned K channels, voltage-gated K (Kv) channels have received the lion's
share of attention to their biophysical properties. Kv and Ca-activated K channel kinetics ... Cited by 28 - Related articles - BL Direct - All 5 versions
