- ►diabetesjournals.org AKH Cheung, MKL Fung, ACY Lo, TTL Lam, KF So, … - Diabetes, 2005 - Am Diabetes Assoc In 15-month-old db/db mice, signs of diabetic retinopathy, including blood-retinal barrier
breakdown, loss of pericytes, neuro-retinal apoptosis, glial reactivation, and proliferation of
blood vessels, were evident. These ... Cited by 50 - Related articles - BL Direct - All 5 versions
N Kato, S Yashima, T Suzuki, Y Nakayama, T … - Journal of Diabetes and its …, 2003 - Elsevier It is important to suppress retinal vascular changes for prevention of the onset and progression of
diabetic retinopathy. In the present study, we investigated the dose–response effect of an aldose
reductase (AR) inhibitor, ... Cited by 32 - Related articles - All 8 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell types when
intracellular glucose concentrations are high, and it can generate cellular stress through several
mechanisms. The role of the polyol ... Cited by 65 - Related articles - BL Direct - All 4 versions
W Sun, C Gerhardinger, Z Dagher, T Hoehn, M Lorenzi - Diabetes, 2005 - Am Diabetes Assoc The prevention of diabetic retinopathy requires drugs that leverage the benefits of glycemic control
without adding the burden of side effects. Aspirin at dosages of 1–1.5 g/day has prevented
manifestations of diabetic retinal ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►iovs.org RA Feit-Leichman, R Kinouchi, M Takeda, Z Fan, S … - … ophthalmology & visual …, 2005 - ARVO RESULTS. There was transient induction of cell apoptosis and caspase-3 activation in retinal neurons
of C57Bl/6 mice within days of diabetes induction. Glial fibrillary acidic protein (GFAP), a marker
of glial activation, likewise was ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►pubget.com [PDF] IG Obrosova, AG Minchenko, R Vasupuram, L White, OI … - Diabetes, 2003 - Am Diabetes Assoc The study addressed the role for aldose reductase (AR) in 1) retinal oxidative stress and vascular
endothelial growth factor (VEGF) overexpression in early diabetes, and 2) high glucose-induced
oxidative stress in retinal ... Cited by 83 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C Gerhardinger, M … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical classes,
spirosuccinamide/hydantoins and carboxylic acids. Each class has its own drawbacks regarding
selectivity, in vivo potency, and ... Cited by 38 - Related articles - BL Direct - All 7 versions
N Oishi, E Kubo, Y Takamura, K Maekawa, T … - British Journal of …, 2002 - bjo.bmj.com Methods: A clinic based cross sectional study was used. 611 NIDDM patients and 73 controls were
enrolled. Erythrocyte AR levels were determined by ELISA. These AR levels were then correlated with
patient age, duration of diabetes, ... Cited by 11 - Related articles - BL Direct - All 8 versions
V Asnaghi, C Gerhardinger, T Hoehn, A Adeboje, M … - Diabetes, 2003 - Am Diabetes Assoc We tested the hypothesis that the apoptosis of inner retina neurons and increased expression of
glial fibrillary acidic protein (GFAP) observed in the rat after a short duration of diabetes are
mediated by polyol pathway ... Cited by 105 - Related articles - BL Direct - All 4 versions
SSM Chung, SK Chung - Current Drug Targets, 2005 - ingentaconnect.com Abstract: Most long-term diabetic patients develop microvascular diseases such as retinopathy,
nephropathy and neuropathy. Although tight control of blood glucose greatly reduces the incidence of
these complications, a significant ... Cited by 38 - Related articles - All 2 versions
