- ►diabetesjournals.org RJ McCrimmon, ML Evans, X Fan, EC McNay, O Chan, … - Diabetes, 2005 - Am Diabetes Assoc The mechanism(s) by which glucosensing neurons detect fluctuations in glucose remains largely
unknown. In the pancreatic β-cell, ATP-sensitive K + channels (K ATP channels) play a key role
in glucosensing by providing a link between neuronal metabolism and membrane ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►nih.gov RJ McCrimmon, Z Song, H Cheng, EC … - Journal of Clinical …, 2006 - Am Soc Clin Investig Recurrent episodes of hypoglycemia impair sympathoadrenal counterregulatory responses
(CRRs) to a subsequent episode of hypoglycemia. For individuals with type 1 diabetes, this markedly
increases (by 25-fold) the risk of severe hypoglycemia and is a major limitation to optimal ... Cited by 29 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org ML Evans, RJ McCrimmon, DE Flanagan, T Keshavarz, … - Diabetes, 2004 - Am Diabetes Assoc It has been postulated that specialized glucose-sensing neurons in the ventromedial hypothalamus
(VMH) are able to detect falling blood glucose and trigger the release of counterregulatory hormones
during hypoglycemia. The molecular mechanisms used by glucose-sensing neurons are ... Cited by 74 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RJ McCrimmon, X Fan, H Cheng, E McNay, O Chan, M … - Diabetes, 2006 - Am Diabetes Assoc Defective counterregulatory responses (CRRs) to hypoglycemia are associated with a marked
increase in the risk of severe hypoglycemia. The mechanisms leading to the development of
defective CRRs remain largely unknown, although they are associated with antecedent ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org NM Sanders, AA Dunn-Meynell, BE Levin - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is hypothesized to be the critical glucosensor of pancreatic β-cells and hypothalamic
glucosensing neurons. To understand the role of GK in glucoprivic counterregulatory
responses, we injected alloxan, a GK inhibitor and toxin, into the third ventricle (3v) to ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►physiology.org R Wang, C Cruciani-Guglielmacci, S … - Journal of …, 2006 - Am Physiological Soc Pharmacological manipulation of fatty acid metabolism in the hypothalamic arcuate nucleus
(ARC) alters energy balance and glucose homeostasis. Thus, we tested the hypotheses that
distinctive populations of ARC neurons are oleic acid (OA) sensors that exhibit a glucose ... Cited by 35 - Related articles - BL Direct - All 4 versions
DMR Rev - Diabetes Metab Res Rev, 2003 - umdnj.edu Diabetes Metab Res Rev 2003; 19: 348–356. Published online 12 August 2003 in Wiley InterScience
(www.interscience.wiley.com). DOI: 10.1002/dmrr.404 ... Departments of Pharmacology & Physiology
and Neurosciences, New Jersey Medical School (UMDNJ), Newark, NJ, USA Cited by 34 - Related articles - View as HTML - BL Direct - All 5 versions
- ►diabetesjournals.org O Chan, M Lawson, W Zhu, JL Beverly, RS Sherwin - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—To determine whether alterations in counterregulatory responses to hypoglycemia
through the modulation of ATP-sensitive K + channels (K ATP channels) in the ventromedial
hypothalamus (VMH) are mediated by changes in GABAergic inhibitory tone in the VMH, ... Cited by 11 - Related articles - BL Direct - All 5 versions
NM Sanders, GJ Taborsky, CW Wilkinson, W Daumen, … - Diabetes, 2007 - Am Diabetes Assoc Recurrent hypoglycemia impairs hormonal counterregulatory responses (CRRs) to further bouts
of hypoglycemia. The hypothalamus and hindbrain are both critical for sensing hypoglycemia
and triggering CRRs. Hypothalamic glucose sensing sites are implicated in the ... Cited by 3 - Related articles - BL Direct - All 5 versions
- ►physiology.org Z Song, VH Routh - American Journal of Physiology- Regulatory, …, 2006 - Am Physiological Soc Recurrent hypoglycemia blunts the brain's ability to sense and respond to subsequent hypoglycemic
episodes. Glucose-sensing neurons in the ventromedial hypothalamus nucleus (VMN) are well
situated to play a role in hypoglycemia detection. VMN glucose-inhibited (GI) neurons, ... Cited by 22 - Related articles - All 5 versions
