A Pocai, K Morgan, C Buettner, R Gutierrez-Juarez, S … - Diabetes, 2005 - Am Diabetes Assoc Voluntary overfeeding rapidly induces resistance to the effects of systemic insulin and leptin
on liver glucose metabolism. To examine whether central administration of recombinant leptin
can restore leptin and insulin action on liver glucose fluxes, we infused leptin in the third ... Cited by 35 - Related articles - BL Direct - All 5 versions
R Gutierrez-Juarez, S Obici, L Rossetti - Journal of Biological Chemistry, 2004 - ASBMB Leptin and insulin share some hypothalamic signaling molecules, but their central administration
induces different effects on hepatic glucose fluxes. Acute insulin infusion in the third cerebral
ventricle inhibits endogenous glucose production (GP), whereas acute leptin infusion ... Cited by 37 - Related articles - BL Direct - All 4 versions
MI Friedman, G Graczyk-Millbrandt, H Ji, NE … - BBA-Molecular Cell …, 2003 - Elsevier To test the hypothesis that decreased hepatocyte ATP is transduced into a hepatic neuronal
signal via a change in sodium pump activity, we examined the effect of 2,5-anhydro- -mannitol
(2,5-AM), which stimulates feeding behavior in rats, on intracellular sodium levels using ... Cited by 6 - Related articles - All 4 versions
H Ji, MI Friedman - Physiology & behavior, 2003 - cat.inist.fr We investigated whether fuel metabolism prior to high-fat feeding differs in outbred
Sprague-Dawley rats either prone or resistant to diet-induced obesity. Chow-fed rats were deprived
of food, and blood was collected 12, 18, and 24 h later. Rats were then fed a high-fat diet ... Cited by 20 - Related articles - All 3 versions
- ►cell.com A Pocai, S Obici, GJ Schwartz, L Rossetti - Cell Metabolism, 2005 - Elsevier Increased glucose production (GP) is the major determinant of fasting hyperglycemia in diabetes
mellitus. Previous studies suggested that lipid metabolism within specific hypothalamic nuclei
is a biochemical sensor for nutrient availability that exerts negative feedback on GP. Here ... Cited by 97 - Related articles - All 9 versions
- ►cell.com GJ Morton, RW Gelling, KD Niswender, CD Morrison, … - Cell Metabolism, 2005 - Elsevier To investigate whether phosphatidylinositol-3 kinase (PI3K) signaling mediates the metabolic
effects of hypothalamic leptin action, adenoviral gene therapy was used to direct expression
of leptin receptors to the area of the hypothalamic arcuate nucleus (ARC). This ... Cited by 64 - Related articles - All 9 versions
- ►nih.gov H Ji, MI Friedman - Metabolism, 2007 - Elsevier High-fat, energy-dense diets promote weight gain and obesity in humans and other animals,
but the mechanisms underlying such diet-induced obesity remain elusive. To determine whether
a reduced capacity to oxidize fat is involved in the etiology of diet-induced obesity, we ... Cited by 17 - Related articles - All 21 versions
C Buettner, A Pocai, ED Muse, AM Etgen, MG Myers, L … - Cell metabolism, 2006 - Elsevier Leptin has pleiotropic effects on glucose homeostasis and feeding behavior. Here, we validate
the use of a cell-permeable phosphopeptide that blocks STAT3 activation in vivo. The combination
of this biochemical approach with stereotaxic surgical techniques allowed us to pinpoint ... Cited by 33 - Related articles - All 11 versions
RW Gelling, GJ Morton, CD Morrison, KD Niswender, … - Cell Metabolism, 2006 - Elsevier To investigate the role of brain insulin action in the pathogenesis and treatment of diabetes, we
asked whether neuronal insulin signaling is required for glucose-lowering during insulin treatment
of diabetes. Hypothalamic signaling via the insulin receptor ... Cited by 33 - Related articles - All 8 versions
A Pocai, TKT Lam, R Gutierrez-Juarez, S Obici, GJ … - Nature, 2005 - nature.com Obesity is the driving force behind the worldwide increase in the prevalence of type 2 diabetes
mellitus 1, 2 . Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepatic
gluconeogenesis 3 . The medial hypothalamus is a major integrator of nutritional and ... Cited by 154 - Related articles - All 7 versions
