- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R Lupi, P … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and type 2 diabetes. It has
been recently suggested that high glucose–induced β-cell apoptosis in type 2 diabetes shares
a final common pathway with type 1 diabetes, involving interleukin-1β (IL-1β) production ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org JA Ehses, A Perren, E Eppler, P Ribaux, JA Pospisilik, … - Diabetes, 2007 - Am Diabetes Assoc Activation of the innate immune system in obesity is a risk factor for the development of type 2
diabetes. The aim of the current study was to investigate the notion that increased numbers of
macrophages exist in the islets of type 2 diabetes patients and that this may be explained ... Cited by 49 - Related articles - BL Direct - All 11 versions
K Maedler, P Sergeev, JA Ehses, Z … - Proceedings of the …, 2004 - National Acad Sciences High concentrations of glucose induce β cell production of IL-1β, leading to impaired β cell function
and apoptosis in human pancreatic islets. IL-1 receptor antagonist (IL-1Ra) is a naturally occurring
antagonist of IL-1β and protects cultured human islets from glucotoxicity. Therefore, the ... Cited by 82 - Related articles - BL Direct - All 13 versions
A Jörns, KJ Rath, O Bock, S Lenzen - Diabetologia, 2006 - Springer Abstract Aims/hypothesis It has recently been proposed that IL-1β may be responsible for beta
cell death in type 2 diabetes mellitus. Major support for this assumption was derived from experiments
in the gerbil Psammomys obesus (sand rat), a model for nutritionally induced non-insulin- ... Cited by 11 - Related articles - All 4 versions
- ►diabetesjournals.org K Maedler, DM Schumann, N Sauter, H Ellingsgaard, D … - Diabetes, 2006 - Am Diabetes Assoc High glucose concentrations have a dual effect on β-cell turnover, inducing proliferation in the
short-term and apoptosis in the long-term. Hyperglycemia leads to β-cell production of interleuking
(IL)-1β in human pancreatic islets. Fas, a death receptor regulated by IL-1β, is involved in ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►jhsph.edu [PDF] CM Larsen, M Faulenbach, A Vaag, A … - The New England …, 2007 - nejm.highwire.org Methods In this double-blind, parallel-group trial involving 70 patients with type 2 diabetes, we
randomly assigned 34 patients to receive 100 mg of anakinra (a recombinant human
interleukin-1–receptor antagonist) subcutaneously once daily for 13 weeks and 36 ... Cited by 144 - Related articles - BL Direct - All 12 versions
H Elouil, AK Cardozo, DL Eizirik, JC Henquin, JC … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Hyperglycaemia and the pro- inflammatory cytokine IL-1β induce similar
alterations of beta cell gene expression, including up-regulation of c-Myc and haeme-oxygenase
1. These effects of hyperglycaemia may result from nuclear factor-kappa B (NFκB) ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Weksler-Zangen, I Raz, S Lenzen, A Jörns, S … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Hyperglycemic Cohen diabetes–sensitive rats exhibited reduced pancreatic weight
with lipid deposits and interleukin-1β–positive macrophage infiltration in the exocrine
pancreas. Islet morphology was preserved, and total pancreatic insulin content did not ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►pnas.org DM Schumann, K Maedler, I Franklin, D … - Proceedings of the …, 2007 - National Acad Sciences Pancreatic β cell mass and function increase in conditions of enhanced insulin demand such
as obesity. Failure to adapt leads to diabetes. The molecular mechanisms controlling this adaptive
process are unclear. Fas is a death receptor involved in β cell apoptosis or proliferation, ... Cited by 21 - Related articles - BL Direct - All 11 versions
K Maedler, DM Schumann, N Sauter, H Ellingsgaard, D … - Diabetes, 2006 - Am Diabetes Assoc T he capacity of the pancreatic -cell to adaptively increase insulin secretion in response to
long- term insulin resistance (for example in obesity) is fundamental to the maintenance of
normogly- cemia. Failure of such a response results in diabetes (1–8). Changes in ... Cited by 9 - Related articles - All 3 versions
