EP Wijekoon, B Hall, S Ratnam, ME Brosnan, SH … - Diabetes, 2005 - Am Diabetes Assoc Mild hyperhomocysteinemia is a risk factor for many diseases, including cardiovascular
disease. We determined the effects of insulin resistance and of type 2 diabetes on homocysteine
(Hcy) metabolism using Zucker diabetic fatty rats (ZDF/Gmi fa/fa and ZDF/Gmi fa/?). ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►jbc.org KM Nieman, MJ Rowling, TA Garrow, KL … - Journal of Biological …, 2004 - ASBMB The hepatic enzyme glycine N-methyltransferase (GNMT) plays a major role in the control of
methyl group and homocysteine metabolism. Because disruption of these vital pathways is associated
with numerous pathologies, understanding GNMT control is important for evaluating ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►physiology.org S Ratnam, EP Wijekoon, B Hall, TA … - American Journal of …, 2006 - Am Physiological Soc Elevation of plasma homocysteine levels has been recognized as an independent risk factor
for the development of cardiovascular disease, a major complication of diabetes. Plasma homocysteine
reflects a balance between its synthesis via S-adenosyl-L-methionine-dependent ... Cited by 19 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org P Tessari, A Coracina, E Kiwanuka, M Vedovato, M … - Diabetes, 2005 - Am Diabetes Assoc Although hyperhomocysteinemia, an independent cardiovascular risk factor, is common in type
2 diabetes with nephropathy, the mechanism(s) of this alteration is not known. In healthy
humans, hyperinsulinemia increases methionine transmethylation, homocysteine ... Cited by 22 - Related articles - BL Direct - All 7 versions
- ►jbc.org S Ratnam, KN Maclean, RL Jacobs, ME Brosnan, … - Journal of Biological …, 2002 - ASBMB Homocysteine metabolism is altered in diabetic patients. Cystathionine -synthase (CBS), a key
enzyme involved in the transsulfuration pathway, which irreversibly converts homocysteine to
cysteine, catalyzes the condensation of serine and homocysteine to cystathionine. ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►nutrition.org KA Tanghe, TA Garrow, KL Schalinske - Journal of Nutrition, 2004 - Am Soc Nutrition Recent studies indicated that hormonal imbalances have a role in modulating the metabolism
of methyl groups and homocysteine, interrelated pathways that when disrupted, are associated
with a number of pathologies. Retinoic acid (RA) was shown to induce hepatic glycine N- ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►nutrition.org MJ Rowling, KL Schalinske - Journal of Nutrition, 2003 - Am Soc Nutrition Perturbation of folate and methyl group metabolism is associated with a number of pathological
conditions, including cardiovascular disease and neoplastic development. Glycine N-methyltransferase
(GNMT) is a key protein that functions to regulate the supply and utilization of methyl ... Cited by 21 - Related articles - BL Direct - All 4 versions
RL Jacobs, LM Stead, C Devlin, I Tabas, ME … - Journal of Biological …, 2005 - ASBMB Biological methylation reactions and homocysteine (Hcy) metabolism are intimately linked. In
previous work, we have shown that phosphatidylethanolamine N-methyltransferase, an enzyme
that methylates phosphatidylethanolamine to form phosphatidylcholine, plays a ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►physiology.org KM Nieman, CS Hartz, SS Szegedi, TA … - American Journal of …, 2006 - Am Physiological Soc A diabetic state induces the activity and abundance of glycine N-methyltransferase (GNMT),
a key protein in the regulation of folate, methyl group, and homocysteine metabolism. Because
the folate-dependent one-carbon pool is a source of methyl groups and 5- ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►nutrition.org CS Hartz, KM Nieman, RL Jacobs, DE Vance, KL … - Journal of …, 2006 - Am Soc Nutrition Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways,
the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine
N-methyltransferase (PEMT). Recent studies have suggested that PEMT is an important ... Cited by 8 - Related articles - BL Direct - All 5 versions
