PJ Beisswenger, KS Drummond, RG Nelson, … - Diabetes, 2005 - Am Diabetes Assoc Dicarbonyl and oxidative stress may play important roles in the development of
diabetes complications, and their response to hyperglycemia could determine
individual susceptibility to diabetic nephropathy. This study examines the ... Cited by 43 - Related articles - BL Direct - All 5 versions
X Wang, K Desai, JT Clausen, L Wu - Kidney international, 2004 - nature.com Blood pressure of spontaneously hypertensive rats (SHR) and paired Wistar Kyoto
(WKY) rats was measured at 5, 8, 13, and 20 weeks of age. HPLC was used to
determine the levels of plasma and kidney MG, as well as reduced or ... Cited by 33 - Related articles - BL Direct - All 4 versions
X Wang, K Desai, T Chang, L Wu - Journal of hypertension, 2005 - journals.lww.com Objectives The pathogenic process of diabetes mellitus is associated with
increased methylglyoxal (MG). MG causes non-enzymic glycation of proteins to
form irreversible advanced glycation endproducts (AGEs). However, the ... Cited by 36 - Related articles - BL Direct - All 3 versions
P Beisswenger, S Howell, R Nelson, M Mauer … - Biochemical Society Transactions, 2003 - bst.portlandpress.com The factors responsible for variable susceptibility to diabetic nephropathy are
not clear. According to the non-enzymatic glycation hypothesis, diabetes-related
tissue damage occurs due to a complex mixture of toxic products, including ... Cited by 49 - Related articles - Cached - BL Direct - All 9 versions
T Chang, R Wang, L Wu - Free Radical Biology and Medicine, 2005 - Elsevier Methylglyoxal (MG) is a metabolite of glucose. Our previous study demonstrated
an elevated MG level with an increased oxidative stress in vascular smooth
muscle cells (VSMCs) from spontaneously hypertensive rats. Whether MG ... Cited by 42 - Related articles - All 4 versions
- ►nrc-cnrc.gc.ca [PDF] L Wu - Canadian journal of physiology and pharmacology, 2005 - article.pubs.nrc-cnrc.gc.ca Abstract: Methylglyoxal (MG), a highly reactive metabolite of glucose, causes
non-enzymatic glycation of proteins to form irreversible advanced glycation
endproducts (AGEs). The present study investigated whether methylglyoxal ... Cited by 24 - Related articles - All 8 versions
M Bourajjaj, C Stehouwer, C Schalkwijk - Biochemical Society Transactions, 2003 - bst.portlandpress.com Various theories have been proposed to explain the hyperglycaemia-induced
pathogenesis of vascular complications of diabetes, including detrimental
effects of AGEs (advanced glycation end products) on vascular tissues. ... Cited by 25 - Related articles - Cached - BL Direct - All 8 versions
L Wu - Canadian journal of physiology and pharmacology, 2006 - article.pubs.nrc-cnrc.gc.ca Abstract: Hypertension is a life-threatening disease that is associated with
increased cardiovascular risks. Causes and mechanisms for hypertension
development remain poorly understood. Methylglyoxal (MG), a highly reactive ... Cited by 14 - Related articles - BL Direct - All 6 versions
T Chang, L Wu - Canadian journal of physiology and pharmacology, 2006 - article.pubs.nrc-cnrc.gc.ca Abstract: Pathogenic mechanisms for essential hypertension are unclear despite
striking efforts from numerous research teams over several decades. Increased
production of reactive oxygen species (ROS) has been associated with the ... Cited by 15 - Related articles - BL Direct - All 7 versions
T Kumagai, M Nangaku, R Inagi - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2008 - interscience.wiley.com Methylglyoxal (MG), a reactive dicarbonyl compound mainly produced by metabolic
pathways, such as glycolysis, binds to proteins or nucleic acids and forms
advanced glycation end products. MG is efficiently metabolized by the ... Cited by 2 - Related articles - BL Direct - All 6 versions
