- ►diabetesjournals.org S Freude, L Plum, J Schnitker, U Leeser, M Udelhoven, … - Diabetes, 2005 - Am Diabetes Assoc Cerebral insulin receptors play an important role in regulation of energy homeostasis and development
of neurodegeneration. Accordingly, type 2 diabetes characterized by insulin resistance is associated
with an increased risk of developing Alzheimer's disease. Formation of neurofibrillary ... Cited by 26 - Related articles - BL Direct - All 6 versions
A Jämsä, K Hasslund, RF Cowburn, A Bäckström, … - … and Biophysical Research …, 2004 - Elsevier The paired helical filaments of highly phosphorylated tau protein are the main components of
neurofibrillary tangles (NFT) in Alzheimer's disease (AD). Protein kinases including glycogen
synthase kinase 3 beta (GSK3β), cyclin-dependent kinase 5 (Cdk5), and c-Jun N-terminal ... Cited by 31 - Related articles - All 5 versions
- ►diabetesjournals.org BJ Clodfelder-Miller, AA Zmijewska, GVW Johnson, RS … - Diabetes, 2006 - Am Diabetes Assoc Deficient signaling by insulin, as occurs in diabetes, is associated with impaired brain
function, and diabetes is associated with an increased prevalence of Alzheimer's disease. One
of the hallmark pathological characteristics of Alzheimer's disease is the presence of ... Cited by 17 - Related articles - BL Direct - All 6 versions
X Zhu, G Perry, MA Smith - Journal of Alzheimer's Disease, 2005 - IOS Press Although cognitive dysfunction in diabetic patients has long since been documented [34], diabetic
compli- cations of the central nervous system (CNS) were not extensively studied until recently
[50]. Future studies are obviously needed given the increased understanding of ... Cited by 15 - Related articles - All 2 versions
- ►diabetesjournals.org J Janson, T Laedtke, JE Parisi, PO'Brien, RC Petersen, … - Diabetes, 2004 - Am Diabetes Assoc Alzheimer disease and type 2 diabetes are characterized by increased prevalence with
aging, a genetic predisposition, and comparable pathological features in the islet and brain
(amyloid derived from amyloid ß protein in the brain in Alzheimer disease and islet ... Cited by 92 - Related articles - BL Direct - All 8 versions
MN Haan - Nature Clinical Practice Neurology, 2006 - nature.com Mary Haan is Professor of Epidemiology at the University of Michigan, School of Public
Health. She received her doctorate in epidemiology in 1986 from the University of California,
School of Public Health in Berkeley. Dr Haan has worked in public health and medicine ... Cited by 32 - Related articles - BL Direct - All 4 versions
P Sivaprakasam, A Xie, RJ Doerksen - Bioorganic & medicinal chemistry, 2006 - Elsevier Glycogen synthase kinase-3α (GSK-3α) was recently found to be an attractive target for the treatment
of Alzheimer's disease due to its dual action in the formation of both amyloid plaques and neurofibrillary
tangles. It is also a viable target for many other diseases, such as type 2 diabetes. ... Cited by 8 - Related articles - All 5 versions
M Lesort, GVW Johnson - Neuroscience, 2000 - Elsevier The modulation of tau phosphorylation and localization in response to insulin-like growth
factor-1 or insulin was examined in primary cultures of rat cortical neurons. Insulin and
insulin-like growth factor-1 treatment resulted in a rapid and transient increase in tau ... Cited by 50 - Related articles - BL Direct - All 4 versions
- ►physiology.org D Dardevet, MC Moore, CA DiCostanzo, B … - American Journal of …, 2005 - Am Physiological Soc Whether glucagon-like peptide (GLP)-1 requires the hepatic portal vein to elicit its insulin
secretion-independent effects on glucose disposal in vivo was assessed in conscious dogs using
tracer and arteriovenous difference techniques. In study 1, six conscious overnight-fasted ... Cited by 12 - Related articles - BL Direct - All 6 versions
C Benedict, M Hallschmid, B Schultes, J Born, … - …, 2007 - content.karger.com Background: Compelling evidence indicates that central nervous insulin enhances learning and
memory and in particular benefits hippocampus-dependent (ie, declarative) memory. Intranasal
administration of insulin provides an effective way of delivering the compound to the ... Cited by 15 - Related articles - BL Direct - All 6 versions
