- ►shouxi.net W Sun, C Gerhardinger, Z Dagher, T Hoehn, … - Diabetes, 2005 - Am Diabetes Assoc The prevention of diabetic retinopathy requires drugs that leverage the benefits
of glycemic control without adding the burden of side effects. Aspirin at
dosages of 1–1.5 g/day has prevented manifestations of diabetic retinal ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org L Zheng, SJ Howell, DA Hatala, K Huang, TS … - Diabetes, 2007 - Am Diabetes Assoc It has been previously reported that aspirin inhibited the development of
diabetic retinopathy in diabetic animals, raising the possibility that
anti-inflammatory drugs may have beneficial effects on diabetic ... Cited by 42 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org TS Kern, CM Miller, Y Du, L Zheng, S Mohr, … - Diabetes, 2007 - Am Diabetes Assoc Pharmacologic treatment of diabetic retinopathy via eyedrops could have
advantages but has not been successful to date. We explored the effect of
topical Nepafenac, an anti-inflammatory drug known to reach the retina when ... Cited by 35 - Related articles - BL Direct - All 4 versions
C Gerhardinger, MB Costa, MC Coulombe, I … - Investigative ophthalmology & visual science, 2005 - ARVO RESULTS. Gene expression profiling identified 78 genes as differentially
expressed in diabetic Müller cells. One third of these genes were associated
with inflammation, including a large cluster (18% of the differentially ... Cited by 75 - Related articles - All 6 versions
BL Mylari, SJ Armento, DA Beebe, EL Conn, … - Journal of medicinal chemistry(Print), 2005 - cat.inist.fr Discovery of a highly selective, potent, and safe non-carboxylic acid,
non-hydantoin inhibitor of aldose reductase(AR) capable of potently blocking the
excess glucose flux through the polyol pathway that prevails under diabetic ... Cited by 18 - Related articles - All 3 versions
M Lorenzi - Current Diabetes Reports, 2006 - Springer Introduction Prevention, a safe prescription for all complications of diabetes,
may be the only efficient prescription for reti- nopathy. Seeking prevention
impacts on many research choices, most importantly on those that inform ... Cited by 2 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org AKH Cheung, MKL Fung, ACY Lo, TTL Lam, … - Diabetes, 2005 - Am Diabetes Assoc In 15-month-old db/db mice, signs of diabetic retinopathy, including
blood-retinal barrier breakdown, loss of pericytes, neuro-retinal apoptosis,
glial reactivation, and proliferation of blood vessels, were evident. These ... Cited by 50 - Related articles - BL Direct - All 5 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell
types when intracellular glucose concentrations are high, and it can generate
cellular stress through several mechanisms. The role of the polyol pathway ... Cited by 65 - Related articles - BL Direct - All 4 versions
N Kato, S Yashima, T Suzuki, Y Nakayama, T … - Journal of Diabetes and its Complications, 2003 - Elsevier It is important to suppress retinal vascular changes for prevention of the onset
and progression of diabetic retinopathy. In the present study, we investigated
the dose–response effect of an aldose reductase (AR) inhibitor, ... Cited by 32 - Related articles - All 8 versions
