- ►diabetesjournals.org H Rahmoune, PW Thompson, JM Ward, CD Smith, G … - Diabetes, 2005 - Am Diabetes Assoc The bulk of glucose that is filtered by the renal glomerulus is reabsorbed by the glucose transporters
of the proximal convoluted tubular epithelium. However, it has been difficult to investigate this
in diseases such as type 2 diabetes because of the inability to isolate primary renal cells ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►endojournals.org HS Freitas, GF Anhe, KFS Melo, MM Okamoto, M … - Endocrinology, 2008 - Endocrine Soc Mutations in Na + -glucose transporters (SGLT)-2 and hepatocyte nuclear factor (HNF)-1 genes
have been related to renal glycosuria and maturity-onset diabetes of the young 3,
respectively. However, the expression of these genes have not been investigated in type ... Cited by 9 - Related articles - BL Direct - All 2 versions
- ►asnjournals.org [PDF] JH Dominguez, B Song, L Maianu, WT Garvey … - Journal of the American …, 1994 - Am Soc Nephrol Page 1. Journal of the American Society of Nephrology S29 Gene Expression of Epithelial
Glucose Transporters: The Role of Diabetes Mellitus Jesus H. Dominguez,1 Buguang Song,
Lidia Maianu, W. Timothy Garvey, and Mona Qulali JH Dominguez, WI. ... Cited by 8 - Related articles - BL Direct - All 7 versions
WT Noonan, VM Shapiro, RO Banks - Life Sciences, 2001 - Elsevier Information regarding the renal glucose transport capacity in diabetes mellitus is limited. These
data are needed because two weeks following injection of streptozotocin (STZ), mRNA and protein
levels of the glucose transporter, GLUT2, are upregulated in the proximal tubule of the rat. ... Cited by 8 - Related articles - All 4 versions
- ►asnjournals.org [PDF] M Kamran, RG Peterson, JH Dominguez - Journal of the American …, 1997 - Am Soc Nephrol Page 1. Overexpression of GLUT2 Gene in Renal Proximal Tubules of Diabetic Zucker Rats
MUHAMMAD KAMRAN,* RICHARD G. PETERSON, and JESUS H. DOMINGUEZ* * Department
of Veterans Affairs, Richard L. Roudebush Medical C'enter and tDepartme,it (f Medicine, ... Cited by 16 - Related articles - BL Direct - All 5 versions
W Meng, BA Ellsworth, AA Nirschl, PJ … - Journal of medicinal …, 2008 - ncbi.nlm.nih.gov The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor
which reduced blood glucose levels in a dose-dependent manner by as much as 55% in hyperglycemic
streptozotocin (STZ) rats. These findings, combined with a favorable ADME profile, have ... Cited by 22 - Related articles - All 4 versions
YJ Lee, HJ Han - Kidney International, 2007 - nature.com Glucose is a key fuel and an important metabolic substrate in mammals. Renal proximal tubular
cells (PTCs) not only reabsorb filtered glucose but are also believed to play a role in the glucotoxicity
associated with renal pathogenesis, such as in diabetes. The proximal tubule ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org R Santer, M Kinner, CL Lassen, R … - Journal of the American …, 2003 - Am Soc Nephrol Renal glucosuria is a "nondisease"; the great majority of affected individuals do not have any
complaints, and only very rarely a propensity to hypovolemia and hypoglycemia has been
described. Renal glucosuria is defined by urinary glucose excretion in the presence of a ... Cited by 47 - Related articles - BL Direct - All 6 versions
T Adachi, K Yasuda, Y Okamoto, N Shihara, A Oku, K … - Metabolism, 2000 - Elsevier The effect of T-1095, an inhibitor of renal glucose reabsorption, on hyperglycemia and the expression
of Na + -glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2) in streptozotocin
(STZ)-induced diabetic rats was examined. There was an elevation of blood glucose, ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org AM Pajor, KM Randolph, SA Kerner, CD Smith - Journal of Pharmacology and …, 2008 - ASPET The kidney contains two Na + /glucose cotransporters, called SGLT2 and SGLT1, arranged in
series along the length of the proximal tubule. The low-affinity transporter, SGLT2, is responsible
for the reabsorption of most of the glucose in the kidney. There is recent interest in SGLT2 ... Cited by 6 - Related articles - All 3 versions
