- ►nih.gov IG Obrosova, VR Drel, P Pacher, O Ilnytska, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the
pathogenesis of diabetes complications, is considered a downstream effector of
oxidative-nitrosative stress. However, some recent findings suggest that it ... Cited by 37 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org F Li, VR Drel, C Szabó, MJ Stevens, IG … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) inhibition has recently been identified as a
novel approach to treatment of experimental peripheral diabetic neuropathy
(PDN). However, long-term inhibition of PARP, an enzyme involved in DNA ... Cited by 25 - Related articles - All 5 versions
- ►pbrc.edu [PDF] IG Obrosova, VR Drel, P Pacher, O Ilnytska, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an im- portant factor in the
pathogenesis of diabetes complica- tions, is considered a downstream effector of
oxidative- nitrosative stress. However, some recent findings suggest that ... Cited by 1 - Related articles - All 3 versions
- ►nih.gov O Ilnytska, VV Lyzogubov, MJ Stevens, VR … - Diabetes, 2006 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental
mechanism in the pathogenesis of diabetes complications including diabetic
neuropathy. This study evaluated the role of PARP in diabetic sensory ... Cited by 26 - Related articles - BL Direct - All 10 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic
neuropathy, but the mechanisms remain unidentified. Here we provide evidence
that poly(ADP-ribose) polymerase (PARP) activation, a downstream effector ... Cited by 87 - Related articles - BL Direct - All 10 versions
- ►shouxi.net E Ho, KSL Lam, YS Chen, JCW Yip, M … - Diabetes, 2006 - Am Diabetes Assoc The exaggerated flux through polyol pathway during diabetes is thought to be a
major cause of lesions in the peripheral nerves. Here, we used aldose reductase
(AR)-deficient (AR −/− ) and AR inhibitor (ARI)-treated mice to further ... Cited by 31 - Related articles - BL Direct - All 7 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and
high-energy phosphates, activates protein kinase C, and affects gene expression
in various tissues. This study was designed to charac- terise the effects ... Cited by 38 - Related articles - BL Direct - All 11 versions
- ►shouxi.net IG Obrosova, O Ilnytska, VV Lyzogubov, IA … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—HFD-fed mice developed obesity, increased plasma FFA and insulin
concentrations, and impaired glucose tolerance. They also had motor and sensory
nerve conduction deficits, tactile allodynia, and thermal hypoalgesia in ... Cited by 20 - Related articles - BL Direct - All 6 versions
IG Obrosova, W Xu, VV Lyzogubov, O Ilnytska, … - Free Radical Biology and Medicine, 2008 - Elsevier Evidence that poly(ADP-ribose) polymerase (PARP) activation plays an important
role in diabetic complications is emerging. This study evaluated the role of
PARP in rat and mouse models of advanced diabetic neuropathy. The orally ... Cited by 15 - Related articles - All 3 versions
