- ►diabetesjournals.org G Boden, P She, M Mozzoli, P Cheung, K Gumireddy, P … - Diabetes, 2005 - Am Diabetes Assoc To study mechanisms by which free fatty acids (FFAs) cause hepatic insulin resistance, we have
used euglycemic-hyperinsulinemic clamping with and without infusion of lipid/heparin (to raise
or to lower plasma FFAs) in alert male rats. FFA-induced hepatic insulin resistance was ... Cited by 148 - Related articles - BL Direct - All 6 versions
- ►physiology.org TKT Lam, H Yoshii, CA Haber, E … - American Journal of …, 2002 - Am Physiological Soc The mechanisms of the impairment in hepatic glucose metabolism induced by free fatty acids
(FFAs) and the importance of FFA oxidation in these mechanisms remain unclear. FFA-induced
peripheral insulin resistance has been linked to membrane translocation of novel protein ... Cited by 97 - Related articles - BL Direct - All 4 versions
MT Nguyen, H Satoh, S Favelyukis, JL Babendure, … - Journal of Biological …, 2005 - ASBMB Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin
resistance. In this study, we treated 3T3-L1 adipocytes with a mixture of free fatty acids
(FFAs) to investigate the molecular mechanisms underlying fat-induced insulin ... Cited by 150 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org XL Wang, L Zhang, K Youker, MX Zhang, J Wang, SA … - Diabetes, 2006 - Am Diabetes Assoc In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined deregulation
of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (FFAs), which
are increased in metabolic syndrome, inhibit insulin signaling and induce metabolic ... Cited by 49 - Related articles - BL Direct - All 4 versions
SI Itani, NB Ruderman, F Schmieder, G Boden - Diabetes, 2002 - Am Diabetes Assoc The possibility that lipid-induced insulin resistance in human muscle is related to alterations
in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers
during euglycemic-hyperinsulinemic clamping in which plasma free fatty acid (FFA) levels ... Cited by 523 - Related articles - BL Direct - All 4 versions
- ►nutrition.org KM Ajuwon, ME Spurlock - Journal of Nutrition, 2005 - Am Soc Nutrition Fatty acids and their metabolites regulate gene expression and immunological pathways.
Furthermore, obese individuals frequently have increased circulating fatty acid
concentrations, and localized inflammation in adipose tissue may facilitate the systemic ... Cited by 65 - Related articles - BL Direct - All 3 versions
- ►endojournals.org Z Gao, X Zhang, A Zuberi, D Hwang, MJ Quon, M … - Molecular …, 2004 - Endocrine Soc Insulin receptor substrate (IRS) has been suggested as a molecular target of free fatty acids
(FFAs) for insulin resistance. However, the signaling pathways by which FFAs lead to the inhibition
of IRS function remain to be established. In this study, we explored the FFA-signaling ... Cited by 158 - Related articles - BL Direct - All 18 versions
- ►nih.gov JK Kim, JJ Fillmore, MJ Sunshine, B … - Journal of Clinical …, 2004 - Am Soc Clin Investig Insulin resistance plays a primary role in the development of type 2 diabetes and may be related
to alterations in fat metabolism. Recent studies have suggested that local accumulation of fat
metabolites inside skeletal muscle may activate a serine kinase cascade involving protein ... Cited by 176 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org H Staiger, K Staiger, N Stefan, HG Wahl, F Machicao, M … - Diabetes, 2004 - Am Diabetes Assoc Obesity-linked insulin resistance is associated with chronic inflammation and cardiovascular
complications. Free fatty acids (FFAs) are prominent candidates for the molecular link between
these disorders. In this study, we determined whether FFAs contribute to vascular ... Cited by 37 - Related articles - BL Direct - All 5 versions
