- ►psu.edu [PDF] CS Nunemaker, M Zhang, DH Wasserman, OP … - Diabetes, 2005 - Am Diabetes Assoc Pulsatile insulin secretion in vivo is believed to be derived, in part, from the
intrinsic glucose-dependent intracellular calcium concentration ([Ca 2+ ] i )
pulsatility of individual islets. In isolation, islets display fast, slow, ... Cited by 24 - Related articles - BL Direct - All 10 versions
GM Dahlgren, LM Kauri, RT Kennedy - BBA-General Subjects, 2005 - Elsevier Glucose induces complex patterns of oscillations in intracellular Ca 2+
concentration ([Ca 2+ ] i ), metabolism and secretion in islets of Langerhans
including “slow” and “fast” pulses with period of 2–5 min and ... Cited by 19 - Related articles - All 3 versions
P Bergsten, J Westerlund, P Liss, PO … - Diabetes, 2002 - Am Diabetes Assoc The role of metabolism in the generation of plasma insulin oscillations was
investigated by simultaneous in vivo recordings of oxygen tension (pO 2 ) in the
endocrine and exocrine pancreas and portal blood insulin concentrations in ... Cited by 17 - Related articles - BL Direct - All 4 versions
CS Nunemaker, LS Satin - Endocrine, 2004 - Springer Received September 8, 2004; Revised September 23, 2004; Accepted September 24,
2004. Author to whom all correspondence and reprint requests should be
addressed: Dr. Leslie S. Satin, Department of Pharmacology and Toxicology, ... Cited by 8 - Related articles - All 3 versions
- ►physiology.org … , DH Wasserman, OP McGuinness, IR Sweet, … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Islets in most species respond to increased glucose with biphasic insulin
secretion, marked by a sharp first-phase peak and a slowly rising second phase.
Mouse islets in vitro, however, lack a robust second phase. To date, this ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►nih.gov CS Nunemaker, R Bertram, A Sherman, K … - Biophysical journal, 2006 - Elsevier Pancreatic islets of Langerhans display complex intracellular calcium changes in
response to glucose that include fast (seconds), slow ( 5 min), and mixed
fast/slow oscillations; the slow and mixed oscillations are likely ... Cited by 16 - Related articles - BL Direct - All 15 versions
- ►nih.gov M Zhang, P Goforth, R Bertram, A Sherman, L … - Biophysical journal, 2003 - Elsevier [Ca 2+ ] i and electrical activity were compared in isolated β-cells and islets
using standard techniques. In islets, raising glucose caused a decrease in [Ca
2+ ] i followed by a plateau and then fast (2–3 min −1 ), slow ... Cited by 51 - Related articles - BL Direct - All 12 versions
- ►nih.gov R Bertram, LS Satin, MG Pedersen, DS … - Biophysical journal, 2007 - Elsevier Insulin secretion from pancreatic β-cells is oscillatory, with a typical period
of 2–7 min, reflecting oscillations in membrane potential and the cytosolic Ca
2+ concentration. Our central hypothesis is that the slow 2–7 min ... Cited by 10 - Related articles - BL Direct - All 17 versions
- ►nih.gov R Bertram, L Satin, M Zhang, P Smolen, A … - Biophysical journal, 2004 - Elsevier Pancreatic islets of Langerhans produce bursts of electrical activity when
exposed to stimulatory glucose levels. These bursts often have a regular
repeating pattern, with a period of 10–60 s. In some cases, however, the ... Cited by 46 - Related articles - BL Direct - All 15 versions
[CITATION] Glucose-induced mixed [Ca^ 2^+]~ c oscillations in mouse beta-cells are controlled by …
MC Beauvois, C Merezak, J Jonas, MA Ravier, … - AMERICAN JOURNAL OF PHYSIOLOGY, 2006 - AMERICAN PHYSIOLOGICAL SOCIETY Cited by 11 - Related articles - BL Direct
