- ►diabetesjournals.org SY Park, YR Cho, HJ Kim, T Higashimori, C … - Diabetes, 2005 - Am Diabetes Assoc Type 2 diabetes is a heterogeneous disease characterized by insulin resistance
and altered glucose and lipid metabolism in multiple organs. To understand the
complex series of events that occur during the development of ... Cited by 53 - Related articles - BL Direct - All 6 versions
- ►physiology.org S Boudina, ED Abel - Physiology, 2006 - Am Physiological Soc Diabetes is a worldwide epidemic (112). Cardiovascular disease remains the major
cause of morbidity and mortality in people with diabetes. Epidemiological
studies suggest that the prevalence of heart failure exceeds that which can ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►endojournals.org J Buchanan, PK Mazumder, P Hu, G … - Endocrinology, 2005 - Endocrine Soc Hyperglycemia is associated with altered myocardial substrate use, a condition
that has been hypothesized to contribute to impaired cardiac performance. The
goals of this study were to determine whether changes in cardiac ... Cited by 69 - Related articles - BL Direct - All 5 versions
ED Abel, SE Litwin, G Sweeney - Physiological Reviews, 2008 - Am Physiological Soc The dramatic increase in the prevalence of obesity and its strong association
with cardiovascular disease have resulted in unprecedented interest in
understanding the effects of obesity on the cardiovascular system. A ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org J Yang, N Sambandam, X Han, RW Gross, M … - Circulation research, 2007 - Am Heart Assoc Obesity-related diabetes mellitus leads to increased myocardial uptake of fatty
acids (FAs), resulting in a form of cardiac dysfunction referred to as lipotoxic
cardiomyopathy. We have shown previously that chronic activation of the FA- ... Cited by 39 - Related articles - All 6 versions
- ►ahajournals.org S Boudina, S Sena, BT O'Neill, P Tathireddy, … - Circulation, 2005 - Am Heart Assoc Methods and Results— Cardiac function, M O 2 , mitochondrial respiration, and
ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts.
Contractile function and M O 2 in glucose-perfused ob/ob hearts were ... Cited by 76 - Related articles - All 10 versions
PK Mazumder, BT O'Neill, MW Roberts, J … - Diabetes, 2004 - Am Diabetes Assoc Diabetes alters cardiac substrate metabolism. The cardiac phenotype in
insulin-resistant states has not been comprehensively characterized. The goal of
these studies was to determine whether the hearts of leptin-deficient ... Cited by 100 - Related articles - BL Direct - All 6 versions
DM Ouwens, C Boer, M Fodor, P De Galan, … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Diabetic cardiomyopathy (DCM) is common in type 2
diabetes. In DCM, insulin resistance may alter cardiac substrate supply and
utilisation leading to changes in myocardial metabolism and cardiac func- ... Cited by 46 - Related articles - All 4 versions
ED Abel - Current Drug Targets-Immune, Endocrine &# 38; …, 2005 - ingentaconnect.com Abstract: Cardiovascular disease is a major cause of mortality and morbidity in
individuals with obesity, type 2 diabetes and the metabolic syndrome. The
mechanisms for this are partially understood, but include increased ... Cited by 28 - Related articles - All 3 versions
- ►nih.gov DM Ouwens, M Diamant, M Fodor, DDJ Habets, … - Diabetologia, 2007 - Springer Page 1. ARTICLE Cardiac contractile dysfunction in insulin-resistant rats fed
a high-fat diet is associated with elevated CD36-mediated ... Cited by 21 - Related articles - BL Direct - All 8 versions
