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Scholar Results 1 - 10 of about 101 related to Steptoe: Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid.... (0.09 sec) 

Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor …

- diabetesjournals.org
RJ Steptoe, JM Ritchie, LK Jones, LC … - Diabetes, 2005 - Am Diabetes Assoc
The nature of the T-cell response to antigen is governed by the activation state
of the antigen-presenting dendritic cell (DC). Immature or resting DCs have been
shown to induce T-cell responses that may protect against the development ...
Cited by 25 - Related articles - All 5 versions

Dendritic cells in human thymus and periphery display a proinsulin epitope in a …

- jimmunol.org
CA Garcia, KR Prabakar, J Diez, ZA Cao, G … - The Journal of Immunology, 2005 - Am Assoc Immnol
The natural expression of tissue-specific genes in the thymus, eg, insulin, is
critical for self-tolerance. The transcription of tissue-specific genes is
ascribed to peripheral Ag-expressing (PAE) cells, which discordant studies ...
Cited by 25 - Related articles - All 6 versions

Prevention of spontaneous autoimmune diabetes in NOD mice by transferring in vitro antigen …

- endojournals.org
G Papaccio, F Nicoletti, F Aurelio Pisanti, K … - Endocrinology, 2000 - Endocrine Soc
To evaluate the effect of antigen-pulsed dendritic cell (DC) transfer on the
development of diabetes, 5-week-old female NOD mice received a single iv
injection of splenic syngeneic DC from euglycemic NOD mice pulsed in vitro ...
Cited by 50 - Related articles - BL Direct - All 2 versions

Proinsulin—a pathogenic autoantigen in type 1 diabetes

- bham.ac.uk [PDF] 
P Narendran, SI Mannering, LC Harrison - Autoimmunity Reviews, 2003 - Elsevier
Type 1 diabetes (T1D) is an autoimmune disease characterised by immunity to
pancreatic β-cell autoantigens, associated with β-cell destruction leading to
insulin deficiency and hyperglycaemia. The rigorous definition of an ...
Cited by 31 - Related articles - All 4 versions

Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive …

- jimmunol.org
J Machen, J Harnaha, R Lakomy, A Styche, M … - The Journal of Immunology, 2004 - Am Assoc Immnol
Phenotypically "immature" dendritic cells (DCs), defined by low cell surface
CD40, CD80, and CD86 can elicit host immune suppression in allotransplantation
and autoimmunity. Herein, we report the most direct means of achieving ...
Cited by 38 - Related articles - BL Direct - All 4 versions

Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and …


J Morin, B Faideau, FL MC GAGNERAULT, … - Clinical and Experimental Immunology, 2003 - pubmedcentral.nih.gov
CD11c + /CD11b + dendritic cells (DC) with high levels of major
histocompatibility complex (MHC) class II and co-stimulatory molecules have been
derived from spleen cells cultured with granulocyte-macrophage colony ...
Cited by 14 - Related articles - BL Direct - All 5 versions

[CITATION] Both exogenous and endogenous interleukin-10 affects the maturation of bone-marrow-derived …


C Haase, TN Jorgensen, BK Michelsen - Immunology, 2002
Cited by 2 - Related articles

Reduced IFN-α secretion by blood dendritic cells in human diabetes


KL Summers, AM Marleau, JL Mahon, R … - Clinical Immunology, 2006 - Elsevier
Characterization of dendritic cells (DC) in human diabetes has been restricted
to monocyte-derived DC in type 1 diabetes, whose physiological relevance to
endogenous DC is uncertain. Here, we provide the first report ...
Cited by 16 - Related articles - All 4 versions

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes

- nih.gov
RJ Steptoe, JM Ritchie, LC Harrison - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig
Bone marrow or hematopoietic stem cell transplantation is a potential treatment
for autoimmune disease. The clinical application of this approach is, however,
limited by the risks associated with allogeneic transplantation. In ...
Cited by 61 - Related articles - BL Direct - All 8 versions

Experimental study on induction of tolerance to experimental autoimmune myasthenia gravis …


L Luoqing, S Shenggang, C Xuebing, W Yunfu, … - Journal of Huazhong University of Science and …, 2005 - Springer
Journal of Huazhong University of Science and Technology [Med Sci] qu N- ~ ~ ~ ~
N: [ N ~ ( ~ ~ i~ ) IN 1 25 (2): 215-218, 2005 ... Experimental Study on
Induction of Tolerance to Experimental ... Autoimmune Myasthenia Gravis by ...
Cited by 4 - Related articles - BL Direct - All 5 versions


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