AK Cardozo, F Ortis, J Storling, YM Feng, J Rasschaert, … - Diabetes, 2005 - Am Diabetes Assoc Cytokines and free radicals are mediators of β-cell death in type 1 diabetes. Under in vitro
conditions, interleukin-1β (IL-1β) + γ-interferon (IFN-γ) induce nitric oxide (NO) production and
apoptosis in rodent and human pancreatic β-cells. We have previously shown, by ... Cited by 102 - Related articles - All 8 versions
- ►ulb.ac.be [PDF] P Pirot, DL Eizirik, AK Cardozo - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: A tight control of endoplas- mic reticulum homeostasis is crucial for
beta cell function and survival. We recently described that IL-1β plus IFN-γ deplete endoplasmic
reticulum Ca 2+ stores in beta cells, leading to endoplasmic reticulum stress and ... Cited by 22 - Related articles - BL Direct - All 5 versions
- ►jbc.org M Cnop, L Ladriere, P Hekerman, F Ortis, AK … - Journal of Biological …, 2007 - ASBMB Free fatty acids cause pancreatic -cell apoptosis and may contribute to -cell loss in type 2 diabetes
via the induction of endoplasmic reticulum stress. Reductions in eukaryotic translation initiation
factor (eIF) 2 phosphorylation trigger -cell failure and diabetes. Salubrinal selectively ... Cited by 44 - Related articles - All 6 versions
- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z Dogusan, M … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes mellitus (T1DM) and
T2DM. In T1DM, cytokines contribute to ß-cell destruction through nuclear factor- B (NF- B)
activation. Previous studies suggested that in T2DM high glucose and free fatty acids ... Cited by 136 - Related articles - BL Direct - All 3 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG Kench, AK … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & JG Kench & AK Busch
& AV Biankin & TJ Biden Received: 21 September 2006 ... Cited by 105 - Related articles - BL Direct - All 5 versions
- ►cell.com KL Lipson, SG Fonseca, S Ishigaki, LX Nguyen, E Foss, … - Cell Metabolism, 2006 - Elsevier In pancreatic β cells, the endoplasmic reticulum (ER) is an important site for insulin biosynthesis
and the folding of newly synthesized proinsulin. Here, we show that IRE1α, an ER-resident protein
kinase, has a crucial function in insulin biosynthesis. IRE1α phosphorylation is coupled to ... Cited by 64 - Related articles - All 13 versions
- ►diabetesjournals.org WC Ladiges, SE Knoblaugh, JF Morton, MJ Korth, BL … - Diabetes, 2005 - Am Diabetes Assoc The endoplasmic reticulum (ER) transmits apoptotic signals in the pancreas during ER
stress, implicating ER stress–mediated apoptosis in the development of diabetes. P58 IPK
(DNAJC3) is induced during ER stress and functions as a negative feedback component ... Cited by 63 - Related articles - All 6 versions
B Kutlu, AK Cardozo, MI Darville, M Kruhoffer … - DIABETES-NEW …, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in type 1 diabetes. In
vitro exposure of insulin-producing INS-1E cells to the cytokines inter- leukin (IL)-1 interferon
(IFN)- leads to a signifi- cant increase in apoptosis. To characterize the genetic networks ... Cited by 91 - Related articles - BL Direct - All 7 versions
- ►nih.gov S Oyadomari, K Takeda, M Takiguchi, T … - Proceedings of the …, 2001 - National Acad Sciences Excessive nitric oxide (NO) production in cytokine-activated β cells has been implicated in β
cell disruption in type 1 diabetes. β cells are very vulnerable to NO-induced apoptosis.
However, the mechanism underlying this phenomenon is unclear. Low concentrations of ... Cited by 263 - Related articles - BL Direct - All 9 versions
