L Herrero, B Rubí, D Sebastián, D Serra, G Asins, P … - Diabetes, 2005 - Am Diabetes Assoc Carnitine palmitoyltransferase I, which is expressed in the pancreas as the liver isoform
(LCPTI), catalyzes the rate-limiting step in the transport of fatty acids into the mitochondria for
their oxidation. Malonyl-CoA derived from glucose metabolism regulates fatty acid ... Cited by 26 - Related articles - All 7 versions
- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A Barbeau, V … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion
(GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid
oxidation, thereby increasing the availability of LC-CoA for lipid signaling to cellular ... Cited by 89 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] B Rubí, PA Antinozzi, L Herrero, H Ishihara, … - Biochemical …, 2002 - pubmedcentral.nih.gov Lipid metabolism in the β-cell is critical for the regulation of insulin secretion. Pancreatic β-cells
chronically exposed to fatty acids show higher carnitine palmitoyltransferase I (CPT I) protein
levels, higher palmitate oxidation rates and an altered insulin response to glucose. We ... Cited by 42 - Related articles - BL Direct - All 8 versions
U Fransson, AH Rosengren, FC Schuit, E Renström, H … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: The molecular mechanisms of insulin release are only partially
known. Among putative factors for coupling glucose metabolism to insulin secretion, anaplerosis
has lately received strong support. The anaplerotic enzyme pyruvate carboxylase is ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►jbc.org JW Joseph, ML Odegaard, SM Ronnebaum, SC … - Journal of Biological …, 2007 - ASBMB It has been proposed that de novo synthesis of long-chain acyl-CoA (LC-CoA) is a signal for
glucose-stimulated insulin secretion (GSIS). Key enzymes involved in synthesis of fatty acids
from glucose include ATP-citrate lyase (CL) and fatty acid synthase (FAS). An inhibitor of ... Cited by 15 - Related articles - All 4 versions
DT Watkins, M Moore - Endocrinology, 1977 - ncbi.nlm.nih.gov Reduced nicotinamide adenine dinucleotide phosphate (NADPH), which stimulated the release
of insulin from toadfish islet cells and from isolated secretion granules, was taken up by the membranes
prepare from these secretion granules. Oxidized nicotinamide adenine dinucleotide ... Cited by 8 - Related articles - All 2 versions
- ►jbc.org H Mulder, D Lu, J Finley IV, J An, J Cohen, PA … - Journal of Biological …, 2001 - ASBMB The long-chain acyl-CoA (LC-CoA) model of glucose-stimulated insulin secretion (GSIS) holds
that secretion is linked to a glucose-induced increase in malonyl-CoA level and accumulation
of LC-CoA in the cytosol. We have previously tested the validity of this proposal by ... Cited by 65 - Related articles - BL Direct - All 3 versions
- ►nih.gov MV Chakravarthy, Y Zhu, M López, L Yin, … - Journal of Clinical …, 2007 - Am Soc Clin Investig 1 Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid
Research, Washington University School of Medicine, St. Louis, Missouri, USA. 2 Department
of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, ... Cited by 33 - Related articles - BL Direct - All 8 versions
FM Ashcroft - Current Opinion in Cell Biology, 1991 - Elsevier Cat + channels and excitation-contraction coupling Frances M. Ashcroft University Laboratory
of Physiology, Oxford, UK The study of Ca2+ channels in the plasma and intracellular membranes
of muscle cells has dramatically advanced our understanding of the mechanism of ... Cited by 9 - Related articles - All 3 versions
CY Lee, F Chasalow, SM Lee, S Lewis, FM … - Molecular and Cellular …, 1980 - Springer * Laboratory of Animal Genetics and § Laboratory of Biochemical Genetics, National Institute
of Environmental Health Sciences, Research Triangle ,Park, North Carolina 27709; t Chemistry
and Life Sciences Group, Research Triangle Institute, Research Triangle Park, North ... Cited by 10 - Related articles - All 2 versions
