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Scholar Results 1 - 10 of about 101 related to Li: β-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotecti.... (0.08 sec) 

β-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective …

- diabetesjournals.org
Y Li, X Cao, LX Li, PL Brubaker, H Edlund, DJ … - Diabetes, 2005 - Am Diabetes Assoc
Glucagon-like peptide-1 (GLP-1) regulates energy intake, gastrointestinal
motility, and nutrient disposal. The relative importance of the islet β-cell
for GLP-1 actions remains unclear. We determined the role of the islet ...
Cited by 71 - Related articles - All 6 versions

Dose–response for glycaemic and metabolic changes 28 days after single injection of long- …


BR Gedulin, P Smith, KS Prickett, M Tryon, S … - Diabetologia, 2005 - Springer
Page 1. Diabetologia (2005) 48: 1380–1385 DOI 10.1007/s00125-005-1795-2 SHORT
COMMUNICATION BR Gedulin . P. Smith . KS Prickett . M. Tryon . S. Barnhill . ...
Cited by 39 - Related articles - BL Direct - All 4 versions

Exendin-4 Uses Irs2 Signaling to Mediate Pancreatic β Cell Growth and Function


S Park, X Dong, TL Fisher, S Dunn, AK Omer, … - Journal of Biological Chemistry, 2006 - ASBMB
The insulin receptor substrate 2 (Irs2) branch of the insulin/insulin-like
growth factor-signaling cascade prevents diabetes in mice because it promotes β
cell replication, function, and survival, especially during metabolic ...
Cited by 65 - Related articles - BL Direct - All 8 versions

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling …


H Wang, M Iezzi, S Theander, PA Antinozzi, … - Diabetologia, 2005 - Springer
Abstract Aims/hypothesis: Mutations in genes encoding HNF-4α, HNF-1α and
IPF-1/Pdx-1 are associated with, re- spectively, MODY subtypes-1, -3 and -4.
Impaired glucose- stimulated insulin secretion is the common primary defect ...
Cited by 29 - Related articles - All 3 versions

A recombinant human glucagon-like peptide (GLP)-1–albumin protein (albugon) mimics …

- diabetesjournals.org
LL Baggio, Q Huang, TJ Brown, DJ Drucker - Diabetes, 2004 - Am Diabetes Assoc
Peptide hormones exert unique actions via specific G protein–coupled
receptors; however, the therapeutic potential of regulatory peptides is
frequently compromised by rapid enzymatic inactivation and clearance from ...
Cited by 94 - Related articles - BL Direct - All 11 versions

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'- …

- endojournals.org
H Hui, A Nourparvar, X Zhao, R Perfetti - Endocrinology, 2003 - Endocrine Soc
The activation of the glucagon-like peptide-1 (GLP-1) receptor has been shown to
have an important role in the functional activity of islet ß-cells and in the
expansion of the islet cell mass. Constant remodeling of islet cell mass is ...
Cited by 141 - Related articles - BL Direct - All 4 versions

Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic β-cell …


J Buteau, ML Spatz, D Accili - Diabetes, 2006 - Am Diabetes Assoc
The glucoincretin hormone glucagon-like peptide-1 (GLP-1) increases pancreatic
β-cell proliferation and survival through sequential activation of the
epidermal growth factor receptor (EGFR), phosphatidylinositol-3 kinase (PI ...
Cited by 47 - Related articles - BL Direct - All 4 versions

Glucagon-like peptide 1 induces pancreatic β-cell proliferation via transactivation of the …

- diabetesjournals.org
J Buteau, S Foisy, E Joly, M Prentki - Diabetes, 2003 - Am Diabetes Assoc
We previously provided evidence that glucagon-like peptide 1 (GLP-1) induces
pancreatic ß-cell growth nonadditively with glucose in a phosphatidylinositol
(PI) 3-kinase- and protein kinase C -dependent manner. However, the exact ...
Cited by 147 - Related articles - BL Direct - All 5 versions

Glucagon-like peptide-1 receptor signaling modulates β cell apoptosis


Y Li, T Hansotia, B Yusta, F Ris, PA Halban, … - Journal of Biological Chemistry, 2003 - ASBMB
Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β
cell mass via activation of β cell proliferation and islet neogenesis. We
examined whether GLP-1 receptor signaling modifies the cellular ...
Cited by 252 - Related articles - BL Direct - All 7 versions

Stimulation of pancreatic {beta}-cell replication by incretins involves transcriptional …

- endocrinology-journals.org
BN Friedrichsen, N Neubauer, YC Lee, VK … - Journal of Endocrinology, 2006 - Soc Endocrinology
The incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic peptide (GIP), have been suggested to act as ß-cell growth
factors and may therefore be of critical importance for the maintenance of ...
Cited by 33 - Related articles - BL Direct - All 4 versions


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