A Takahashi, K Motomura, T Kato, T Yoshikawa, Y … - Diabetes, 2005 - Am Diabetes Assoc Influx of excess fatty acids and the resultant accumulation of intracellular triglycerides are linked
to impaired insulin secretion and action in the pathogenesis of type 2 diabetes. Sterol regulatory
element-binding protein (SREBP)-1c is a transcription factor that controls cellular ... Cited by 43 - Related articles - All 5 versions
- ►umin.ac.jp [PDF] T Kato, H Shimano, T Yamamoto, T Yokoo, Y Endo, M … - Cell Metabolism, 2006 - Elsevier Granuphilin is a crucial component of the docking machinery of insulin-containing vesicles to
the plasma membrane. Here, we show that the granuphilin promoter is a target of
SREBP-1c, a transcription factor that controls fatty acid synthesis, and MafA, a β cell ... Cited by 25 - Related articles - All 8 versions
- ►endojournals.org T Yamashita, K Eto, Y Okazaki, S Yamashita, T … - Endocrinology, 2004 - Endocrine Soc Triglyceride (TG) accumulation in pancreatic ß-cells is thought to be associated with impaired
insulin secretory response to glucose (lipotoxicity). To better understand the mechanism of the
impaired insulin secretory response to glucose in ß-cell lipotoxicity, we overexpressed a ... Cited by 51 - Related articles - BL Direct - All 3 versions
H Wang, P Maechler, PA Antinozzi, L Herrero, KA … - Journal of Biological …, 2003 - ASBMB Accumulation of lipids in non-adipose tissues is often associated with Type 2 diabetes and its
complications. Elevated expression of the lipogenic transcription factor, sterol regulatory element
binding protein-1c (SREBP-1c), has been demonstrated in islets and liver of diabetic ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Zitzer, W Wente, MB Brenner, S Sewing, K Buschard, … - Endocrinology, 2006 - Endocrine Soc Liver X receptors (LXR and LXRß) regulate glucose and lipid metabolism. Pancreatic ß-cells
and INS-1E insulinoma cells express only the LXRß isoform. Activation of LXRß with the synthetic
agonist T0901317 increased glucose-induced insulin secretion and insulin content, ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org T Kato, H Shimano, T Yamamoto, M Ishikawa, S … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Incubation of C57BL/6 islets with palmitate caused inhibition of both glucose- and
potassium-stimulated insulin secretion, but addition of eicosapentaenoate (EPA) restored both
inhibitions. Concomitantly, palmitate activated and EPA abolished both mRNA and ... Cited by 11 - Related articles - All 6 versions
- ►nih.gov [PDF] F Diraison, L Parton, P Ferré, F Foufelle, CP … - Biochemical …, 2004 - pubmedcentral.nih.gov Accumulation of intracellular lipid by pancreatic islet β-cells has been proposed to inhibit normal
glucose-regulated insulin secretion ('glucolipotoxicity'). In the present study, we determine whether
over-expression in rat islets of the lipogenic transcription factor SREBP1c ... Cited by 55 - Related articles - BL Direct - All 8 versions
MB Sandberg, J Fridriksson, L Madsen, V Rishi, C … - Molecular and cellular …, 2005 - Elsevier Here we investigate the role of sterol-regulatory element binding proteins in glucose-induced
lipogenesis in the pancreatic β-cell line INS-1E. We show that glucose induces SREBP-1c expression
and SREBP-1 activity independent of insulin secretion and signaling. Using adenoviral ... Cited by 17 - Related articles - All 3 versions
H Shimano, M Amemiya-Kudo, A Takahashi, … - Diabetes Obes …, 2007 - interscience.wiley.com It has long been known that excess intracellular fatty acids cause impaired insulin secretion,
referred to as β-cell lipotoxicity. Sterol regulatory element–binding protein (SREBP)-1c is a transcription
factor that controls hepatic fatty acid synthesis. Activation of SREBP-1c by overnutrition ... Cited by 10 - Related articles - All 2 versions
