TL Yue, W Bao, JL Gu, J Cui, L Tao, XL Ma, EH … - Diabetes, 2005 - Am Diabetes Assoc The mechanism responsible for the enhanced myocardial susceptibility to ischemic insult in patients
with type 2 diabetes is not clear. The present study examines the effect of rosiglitazone treatment
on cardiac insulin sensitization and its association with cardioprotection from ischemia/ ... Cited by 76 - Related articles - All 6 versions
- ►diabetesjournals.org RJ Sidell, MA Cole, NJ Draper, M Desrois, RE … - Diabetes, 2002 - Am Diabetes Assoc Obesity is associated with risk factors for cardiovascular disease, including insulin
resistance, and can lead to cardiac hypertrophy and congestive heart failure. Here, we used
the insulin-sensitizing agent rosiglitazone to investigate the cellular mechanisms linking ... Cited by 101 - Related articles - BL Direct - All 6 versions
- ►physiology.org B Molavi, J Chen, JL Mehta - American Journal of Physiology- …, 2006 - Am Physiological Soc Current evidence points to renin-angiotensin system as a key mediator in ischemia-reperfusion
injury. Rosiglitazone, a peroxisome proliferator-activated receptor- (PPAR- ) ligand, has recently
been shown to confer cardioprotection against ischemia-reperfusion in animal models. ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►physiology.org JJM Greer, DP Ware, DJ Lefer - American Journal of Physiology- …, 2006 - Am Physiological Soc Clinical studies have reported that the incidence and severity of myocardial infarction is significantly
greater in diabetics compared with nondiabetics after correction for all other risk factors. The
majority of studies investigating the pathophysiology of myocardial ischemia-reperfusion ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►physiology.org P Wang, JC Chatham - American Journal of Physiology- …, 2004 - Am Physiological Soc The aim of this study was to determine whether the transition from insulin resistance to hyperglycemia
in a model of type 2 diabetes leads to intrinsic changes in the myocardium that increase the sensitivity
to ischemic injury. Hearts from 6-, 12-, and 24-wk-old lean (Control) and obese Zucker ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►physiology.org GD Thakker, NG Frangogiannis, M Bujak, … - American Journal of …, 2006 - Am Physiological Soc Epidemiological studies indicate that obesity, insulin resistance, and diabetes are important comorbidities
of patients with ischemic heart disease and increase mortality and development of congestive
heart failure after myocardial infarction. Although ob/ob and db/db mice are commonly ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►physiology.org Y Xu, M Gen, L Lu, J Fox, SO Weiss, RD … - American Journal of …, 2005 - Am Physiological Soc Peroxisome proliferator-activated receptor (PPAR)- modulates substrate metabolism and inflammatory
responses. In experimental rats subjected to myocardial ischemia-reperfusion (I/R), thiazolidinedione
PPAR- activators reduce infarct size and preserve left ventricular function. Troglitazone is ... Cited by 29 - Related articles - All 4 versions
- ►physiology.org AD Hafstad, AM Khalid, OJ How, TS … - American Journal of …, 2007 - Am Physiological Soc Hearts from type 2 diabetic (db/db) mice demonstrate altered substrate utilization with high rates
of fatty acid oxidation, decreased functional recovery following ischemia, and reduced cardiac
efficiency. Although db/db mice show overall insulin resistance in vivo, we recently ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►physiology.org SP Jones, WG Girod, DN Granger, AJ … - American Journal of …, 1999 - Am Physiological Soc We examined the mechanisms responsible for myocardial ischemia-reperfusion (MI-R) injury
in a well-characterized animal model of type II diabetes mellitus. Diabetic (db/db) mice and their
littermate nondiabetic controls were subjected to 30 min of left anterior descending ... Cited by 56 - Related articles - BL Direct - All 3 versions
OJ How, E Aasum, DL Severson, WY Chan, MF Essop, … - Diabetes, 2006 - Am Diabetes Assoc Altered cardiac metabolism and function (diabetic cardiomyopathy) has been observed in
diabetes. We hypothesize that cardiac efficiency, the ratio of cardiac work (pressure-volume area
[PVA]) and myocardial oxygen consumption (MVo 2 ), is reduced in diabetic hearts. ... Cited by 58 - Related articles - BL Direct - All 5 versions
