- ►diabetesjournals.org SA Summers, DH Nelson - Diabetes, 2005 - Am Diabetes Assoc Metabolic syndrome X and type 2 diabetes share many metabolic and morphological similarities
with Cushing's syndrome, a rare disorder caused by systemic glucocorticoid excess. Pathologies
frequently associated with these diseases include insulin resistance, atherosclerosis, ... Cited by 46 - Related articles - All 10 versions
SA Summers, DH Nelson - DIABETES, 2005 - Am Diabetes Assoc Metabolic syndrome X and type 2 diabetes share many metabolic and morphological similarities
with Cushing's syndrome, a rare disorder caused by systemic glucocor- ticoid excess. Pathologies
frequently associated with these diseases include insulin resistance, atherosclero- sis, ... Related articles
- ►jbc.org JA Chavez, WL Holland, J Bar, K Sandhoff, SA … - Journal of Biological …, 2005 - ASBMB Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation
of lipids in tissues not suited for fat storage, such as skeletal muscle and the liver. To elucidate
the mechanisms linking exogenous fats to the inhibition of insulin action, we evaluated ... Cited by 55 - Related articles - All 6 versions
M Straczkowski, I Kowalska, A Nikolajuk, S Dzienis- … - Diabetes, 2004 - Am Diabetes Assoc In vitro studies revealed that insulin resistance might be associated with the intracellular formation
of ceramide, the second messenger in the sphingomyelin signaling pathway. The aim of the
present study was to examine the content and composition of fatty acids in ceramide and ... Cited by 68 - Related articles - BL Direct - All 5 versions
M Gorska, A Dobrzyń, M Zendzian-Piotrowska … - … and metabolic research …, 2004 - ncbi.nlm.nih.gov AIMS/HYPOTHESIS: Ceramide is the main second messenger in the sphingomyelin-transmembrane
signalling pathway. The compound is likely to play a role in the induction of insulin
resistance. The aim of the present study was to examine the effect of streptozotocin ... Cited by 18 - Related articles - BL Direct - All 4 versions
JW Helge, A Dobrzyn, B Saltin, J … - Experimental physiology, 2004 - expphysiol.highwire.org In rat skeletal muscle prolonged exercise affects the content and composition of ceramides, but
in human skeletal muscle no data are available on this compound. Our aim was to examine the
content of ceramide- and sphingomyelin fatty acids and neutral, Mg 2+ -dependent ... Cited by 20 - Related articles - BL Direct - All 10 versions
F Samad, KD Hester, G Yang, YA Hannun, J Bielawski - Diabetes, 2006 - Am Diabetes Assoc The adipose tissue has become a central focus in the pathogenesis of obesity-mediated cardiovascular
and metabolic disease. Here we demonstrate that adipose sphingolipid metabolism is altered
in genetically obese (ob/ob) mice. Expression of enzymes involved in ceramide ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►jbc.org S Stratford, KL Hoehn, F Liu, SA Summers - Journal of Biological Chemistry, 2004 - ASBMB The sphingolipid ceramide negatively regulates insulin action by inhibiting Akt/protein kinase
B (PKB), a serine/threonine kinase that is a central regulator of glucose uptake and anabolic
metabolism. Despite considerable attention, the molecular mechanism accounting for this ... Cited by 69 - Related articles - BL Direct - All 4 versions
H Wang, LA Knaub, DR Jensen, D Young Jung, EG … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Nine-week-old SMLPL −/− mice showed no differences in body weight, fat
mass, or whole-body insulin sensitivity, but older SMLPL −/− mice had greater weight gain and
whole-body insulin resistance. High-fat diet feeding accelerated the development of ... Cited by 13 - Related articles - All 5 versions
H Sawai, N Domae, T Okazaki - Current pharmaceutical design, 2005 - ingentaconnect.com Abstract: Ceramide is not only structurally but also functionally a key molecule in diverse kinds
of sphingolipids. In the past decade, ceramide has been shown to be of crucial significance in
several cell functions including apoptosis, cell growth, senescence, and cell cycle control. ... Cited by 17 - Related articles - All 3 versions
