- ►diabetesjournals.org LJ Hampson, L Agius - Diabetes, 2005 - Am Diabetes Assoc Glucokinase and phosphorylase both have a high control strength over hepatocyte glycogen
metabolism and are potential therapeutic targets for type 2 diabetes. We tested whether combined
phosphorylase inactivation and glucokinase activation is a more effective strategy for ... Cited by 10 - Related articles - All 5 versions
- ►nih.gov [PDF] S Aiston, A Green, M Mukhtar, L Agius - Biochemical Journal, 2004 - pubmedcentral.nih.gov The role of glucose 6-P (glucose 6-phosphate) in regulating the activation state of glycogen synthase
and its translocation is well documented. In the present study, we investigated the effects of glucose
6-P on the activation state and compartmentation of phosphorylase in hepatocytes. ... Cited by 16 - Related articles - BL Direct - All 8 versions
L Harndahl, D Schmoll, AW Herling, L Agius - FEBS JOURNAL, 2006 - interscience.wiley.com Pharmacological activation or overexpression of glucokinase in hepatocytes stimulates glucose
phosphorylation, glycolysis and glycogen synthesis. We used an inhibitor of glucose 6-phosphate
(Glc6P) hydrolysis, namely the chlorogenic derivative, 1-[2-(4-chloro-phenyl)- ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Aiston, B Andersen, L Agius - Diabetes, 2003 - Am Diabetes Assoc High glucose concentration suppresses hepatic glycogenolysis by allosteric inhibition and dephosphorylation
(inactivation) of phosphorylase-a. The latter effect is attributed to a direct effect of glucose on
the conformation of phosphorylase-a. Although glucose-6-phosphate (G6P), like glucose, ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►physiology.org MC Moore, K Kimura, H Shibata, T Honjoh … - American Journal of …, 2005 - Am Physiological Soc Intraportal serotonin infusion enhances net hepatic glucose uptake (NHGU) during glucose infusion
but blunts nonhepatic glucose uptake and can cause gastrointestinal discomfort and diarrhea
at high doses. Whether the serotonin precursor 5-hydroxytryptophan (5-HTP) could ... Cited by 4 - Related articles - BL Direct - All 5 versions
MC Moore, WB Geho, M Lautz, B Farmer, DW Neal, AD … - Diabetes, 2004 - Am Diabetes Assoc Whether serotonin (5-hydroxytryptamine [5-HT]) enhances net hepatic glucose uptake
(NHGU) during glucose infusion was examined in conscious 42-h-fasted dogs, using arteriovenous
difference and tracer ([3- 3 H]glucose) techniques. Experiments consisted of equilibration ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►physiology.org MC Moore, CA DiCostanzo, D Dardevet, … - American Journal of …, 2004 - Am Physiological Soc Intraportal delivery of serotonin enhanced net hepatic glucose uptake (NHGU) during a hyperinsulinemic
hyperglycemic clamp, but serotonin elevated catecholamines and can cause gastrointestinal
distress. We hypothesized that the selective serotonin reuptake inhibitor (SSRI) ... Cited by 7 - Related articles - BL Direct - All 4 versions
[CITATION] Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase
WH Martin, DJ Hoover, SJ Armento, IA Stock, RR … - Proc Natl Acad Sci USA, 1998 Cited by 7 - Related articles
- ►nih.gov [PDF] T Latsis, B Andersen, L Agius - Biochemical Journal, 2002 - pubmedcentral.nih.gov Two distinct allosteric inhibitors of glycogen phosphorylase, 1,4-dideoxy-1,4-imino--arabinitol
(DAB) and CP-91149 (an indole-2-carboxamide), were investigated for their effects on the phosphorylation
state of the enzyme in hepatocytes in itro. CP-91149 induced inactivation ( ... Cited by 25 - Related articles - BL Direct - All 8 versions
E Van Schaftingen - European Journal of Biochemistry, 1995 - interscience.wiley.com The purpose of this study was to identify the mechanism by which proglycosyn and resorcinol
decrease the phosphorylase a content and the fructose 2,6-bisphosphate concentration in isolated
hepatocytes. The intracellular concentrations of the glucuronide derivatives of ... Cited by 9 - Related articles - BL Direct - All 5 versions
