- ►shouxi.net E Oh, BA Spurlin, JE Pessin, DC Thurmond - Diabetes, 2005 - Am Diabetes Assoc The disruption of Munc18c binding to syntaxin 4 impairs insulin-stimulated GLUT4
vesicle translocation in 3T3L1 adipocytes. To investigate the physiological
function and requirement for Munc18c in the regulation of GLUT4 ... Cited by 33 - Related articles - All 6 versions
- ►jbc.org E Oh, DC Thurmond - Journal of Biological Chemistry, 2006 - ASBMB Stimulus-induced tyrosine phosphorylation of Munc18c was investigated as a
potential regulatory mechanism by which the Munc18c-Syntaxin 4 complex can be
dissociated in response to divergent stimuli in multiple cell types. Use of ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org BA Spurlin, SY Park, AK Nevins, JK Kim, DC … - Diabetes, 2004 - Am Diabetes Assoc Insulin-stimulated translocation of GLUT4 vesicles from an intracellular
compartment to the plasma membrane in 3T3L1 adipocytes is mediated through a
syntaxin 4 (Syn4)- and Munc18c-dependent mechanism. To investigate the ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►endojournals.org BA Spurlin, DC Thurmond - Molecular Endocrinology, 2006 - Endocrine Soc Numerous overexpression studies have recently implicated Syntaxin 4 as an
effector of insulin secretion, although its requirement in insulin granule
exocytosis is unknown. To address this, islets from Syntaxin 4 heterozygous ... Cited by 21 - Related articles - BL Direct - All 4 versions
B Ke, E Oh, DC Thurmond - Journal of Biological Chemistry, 2007 - ASBMB The widely expressed Sec/Munc18 (SM) protein Munc18c is required for
SNARE-mediated insulin granule exocytosis from islet beta cells and GLUT4
vesicle exocytosis in skeletal muscle and adipocytes. Although Munc18c ... Cited by 10 - Related articles - All 5 versions
- ►nih.gov DC Thurmond, M Kanzaki, AH Khan, JE … - Molecular and Cellular Biology, 2000 - Am Soc Microbiol To examine the functional role of the interaction between Munc18c and syntaxin 4
in the regulation of GLUT4 translocation in 3T3L1 adipocytes, we assessed the
effects of introducing three different peptide fragments (20 to 24 amino ... Cited by 76 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org BA Spurlin, RM Thomas, AK Nevins, HJ Kim, … - Diabetes, 2003 - Am Diabetes Assoc To investigate the physiological effects of modulating the abundance of Munc18c
or syntaxin 4 (Syn4) proteins on the regulation of glucose homeostasis in vivo,
we generated tetracycline-repressible transgenic mice that overexpress ... Cited by 24 - Related articles - BL Direct - All 4 versions
DC Thurmond, JE Pessin - The EMBO Journal, 2000 - pubmedcentral.nih.gov To examine the temporal relationship between pre- and post-docking events, we
generated a Munc18c temperature-sensitive mutant (Munc18c/TS) by substitution of
arginine 240 with a lysine residue. At the permissive temperature (23°C), ... Cited by 39 - Related articles - BL Direct - All 5 versions
CF Latham, JA Lopez, SH Hu, CL Gee, E … - Traffic, 2006 - interscience.wiley.com Sec1p/Munc18 (SM) proteins are believed to play an integral role in vesicle
transport through their interaction with SNAREs. Different SM proteins have been
shown to interact with SNAREs via different mechanisms, leading to the ... Cited by 48 - Related articles - BL Direct - All 3 versions
- ►nih.gov H Kanda, Y Tamori, H Shinoda, M Yoshikawa, … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Insulin-stimulated glucose uptake in adipocytes is mediated by translocation of
vesicles containing the glucose transporter GLUT4 from intracellular storage
sites to the cell periphery and the subsequent fusion of these vesicles ... Cited by 74 - Related articles - All 12 versions
