- ►diabetesjournals.org K Ozawa, M Miyazaki, M Matsuhisa, K Takano, Y … - Diabetes, 2005 - Am Diabetes Assoc To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model
of type 2 diabetes, were mated with either heterozygous knockout mice or two types of transgenic
mice of 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone located in ... Cited by 68 - Related articles - All 5 versions
Y Nakatani, H Kaneto, D Kawamori, K Yoshiuchi, M … - Journal of Biological …, 2005 - ASBMB Type 2 diabetes is one of the most prevalent and serious metabolic diseases in the world, and
insulin resistance and pancreatic -cell dysfunction are the hallmarks of the disease. In this
study, we have shown that endoplasmic reticulum (ER) stress, which is provoked under ... Cited by 144 - Related articles - All 5 versions
U Ozcan, E Yilmaz, L Ozcan, M Furuhashi, E … - Science, 2006 - sciencemag.org Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type
2 diabetes. Here, we provide evidence that this mechanistic link can be exploited for therapeutic
purposes with orally active chemical chaperones. 4-Phenyl butyric acid and taurine- ... Cited by 276 - Related articles - BL Direct - All 8 versions
- ►upenn.edu [PDF] U Ozcan, Q Cao, E Yilmaz, AH Lee, NN Iwakoshi, … - Science's …, 2004 - stke.sciencemag.org Abstract: Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms
are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic
reticulum (ER) stress. This stress in turn leads to suppression of insulin receptor signaling ... Cited by 600 - Related articles - All 17 versions
H Kaneto, T Matsuoka, Y Nakatani, D Kawamori, T … - Journal of Molecular …, 2005 - Springer Page 1. J Mol Med (2005) 83: 429–439 DOI 10.1007/s00109-005-0640-x REVIEW Hideaki Kaneto .
Taka-aki Matsuoka . Yoshihisa Nakatani . Dan Kawamori . Takeshi Miyatsuka . Munehide
Matsuhisa . Yoshimitsu Yamasaki Oxidative stress, ER stress, and the JNK pathway in ... Cited by 47 - Related articles - All 3 versions
Y Nakatani, H Kaneto, D Kawamori, M Hatazaki, T … - Journal of Biological …, 2004 - ASBMB The c-Jun N-terminal kinase (JNK) pathway is known to be activated under diabetic conditions
and to possibly be involved in the progression of insulin resistance. In this study, we examined
the effects of modulation of the JNK pathway in liver on insulin resistance and glucose ... Cited by 80 - Related articles - BL Direct - All 4 versions
- ►physiology.org SJ Marciniak, D Ron - Physiological reviews, 2006 - Am Physiological Soc The extracellular space is an environment hostile to unmodified polypeptides. For this
reason, many eukaryotic proteins destined for exposure to this environment through secretion
or display at the cell surface require maturation steps within a specialized organelle, the ... Cited by 182 - Related articles - BL Direct - All 6 versions
M Tamatani, T Matsuyama, A Yamaguchi, N Mitsuda, Y … - Nature Medicine, 2001 - nature.com Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum−associated chaperone
induced by hypoxia/ischemia. Although ORP150 was sparingly upregulated in neurons from
human brain undergoing ischemic stress, there was robust induction in astrocytes. ... Cited by 101 - Related articles - BL Direct - All 3 versions
- ►jbc.org Y Lin, AH Berg, P Iyengar, TKT Lam, A Giacca, TP … - Journal of Biological …, 2005 - ASBMB Hyperglycemia is a major independent risk factor for diabetic macrovascular disease. The consequences
of exposure of endothelial cells to hyperglycemia are well established. However, little is known
about how adipocytes respond to both acute as well as chronic exposure to physiological ... Cited by 152 - Related articles - All 6 versions
- ►diabetesjournals.org WC Ladiges, SE Knoblaugh, JF Morton, MJ Korth, BL … - Diabetes, 2005 - Am Diabetes Assoc The endoplasmic reticulum (ER) transmits apoptotic signals in the pancreas during ER
stress, implicating ER stress–mediated apoptosis in the development of diabetes. P58 IPK
(DNAJC3) is induced during ER stress and functions as a negative feedback component ... Cited by 63 - Related articles - All 6 versions
