X Zhang, JP Gaspard, Y Mizukami, J Li, F Graeme- … - Diabetes, 2005 - Am Diabetes Assoc Cyclin D1 can stimulate proliferation by driving cells from the G1 into the S-phase of the mammalian
cell cycle. Previous animal studies have implicated the G1-S transition as a key regulatory checkpoint
governing the proliferation of pancreatic islet cells. We expressed cyclin D1 in the β-cells ... Cited by 32 - Related articles - All 5 versions
I Cozar-Castellano, M Weinstock, M Haught… - Diabetes, 2006 - ncbi.nlm.nih.gov We hypothesized that combined transgenic overexpression of hepatocyte growth factor
(HGF) and placental lactogen in islets would lead to even greater increases in beta-cell mass
and replication than either growth factor alone. This did not occur, suggesting that ... Cited by 22 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org I Cozar-Castellano, KK Takane, R Bottino, AN … - Diabetes, 2004 - Am Diabetes Assoc The major regulator of the gap-1/synthesis phase (G 1 /S) cell cycle checkpoint is the retinoblastoma
protein (pRb), and this is regulated in part by the activities of cyclin-dependent kinase (cdk)-4
and the D cyclins. Surprisingly, given the potential importance of ß-cell replication for islet ... Cited by 57 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, AF … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21, p27) are critical
for normal regulation of β-cell proliferation, mass, and function. The retinoblastoma protein,
pRb, is positioned at the very end of a cascade of these regulatory proteins and is ... Cited by 12 - Related articles - BL Direct - All 5 versions
[CITATION] Induction of-cell proliferation and retinoblastoma protein phosphorylation in rat and …
- ►diabetesjournals.org S Fatrai, L Elghazi, N Balcazar, C Cras-Méneur, I Krits, … - Diabetes, 2006 - Am Diabetes Assoc Proliferation is the major component for maintenance of β-cell mass in adult animals. Activation
of phosphoinositide 3-kinase/Akt-kinase pathway is a critical regulator of β-cell mass. Pancreatic
β-cell overexpression of constitutively active Akt in mice (caAkt Tg ) resulted in marked ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►nih.gov JA Kushner, MA Ciemerych, E Sicinska, LM … - Molecular and Cellular …, 2005 - Am Soc Microbiol Regulation of adult ß-cell mass in pancreatic islets is essential to preserve sufficient insulin secretion
in order to appropriately regulate glucose homeostasis. In many tissues mitogens influence development
by stimulating D-type cyclins (D1, D2, or D3) and activating cyclin-dependent kinases ... Cited by 115 - Related articles - All 7 versions
- ►nih.gov A Iglesias, M Murga, U Laresgoiti, A … - Journal of Clinical …, 2004 - Am Soc Clin Investig 1 Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of
Sciences, University of the Basque Country, Bilbao, Spain. 2 Unitat de Biologia Cellular I
Molecular, Institut Municipal d'Investigació Mèdica, Universitat Pompeu Fabra, Barcelona, ... Cited by 38 - Related articles - BL Direct - All 9 versions
Y Fujinaka, D Sipula, A Garcia-Ocaña, RC Vasavada - Diabetes, 2004 - Am Diabetes Assoc Transgenic overexpression of either parathyroid hormone-related peptide (PTHrP) or mouse
placental lactogen type 1 (mPL1) in pancreatic β-cells, using the rat insulin II promoter (RIP),
results in islet hyperplasia either through prolonged β-cell survival or through increased β- ... Cited by 28 - Related articles - BL Direct - All 5 versions
[CITATION] Loss of expression of cdk4 causes insulin-deficient diabetes and cdk4 activation …
