- ►diabetesjournals.org J Domínguez-Bendala, D Klein, M Ribeiro, C Ricordi, L … - Diabetes, 2005 - Am Diabetes Assoc Stem cell technologies hold great potential for the treatment of type 1 diabetes, provided that
functional transplantable ß-cells can be selectively generated in an efficient manner. Such a
process should recapitulate, at least to a certain extent, the embryonic development of ß- ... Cited by 44 - Related articles - All 5 versions
J Dome - 糖尿病学杂志, 2005 - journal.shouxi.net Stem cell technologies hold great potential for the treatment of type 1 diabetes, provided that
functional transplantable -cells can be selectively generated in an efficient manner. Such a process
should recapitulate, at least to a certain extent, the embryonic development of -cells in ... Related articles - Cached
- ►diabetesjournals.org H Noguchi, S Bonner-Weir, FY Wei, M Matsushita, S … - Diabetes, 2005 - Am Diabetes Assoc BETA2/NeuroD, a basic helix-loop-helix transcription factor, is a key regulator of pancreatic islet
morphogenesis and insulin gene transcription. Here we report for the first time that the
BETA2/NeuroD protein can permeate several cells, including pancreatic islets, due to an ... Cited by 35 - Related articles - BL Direct - All 6 versions
H Noguchi, H Kaneto, GC Weir, S Bonner-Weir - Diabetes, 2003 - Am Diabetes Assoc The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1/IPF1,
a homeodomain-containing transcription factor, plays a central role in regulating pancreatic development
and insulin gene transcription. Furthermore, even in adults, PDX-1 is associated with islet ... Cited by 109 - Related articles - BL Direct - All 6 versions
J Imai, H Katagiri, T Yamada, Y Ishigaki, T Ogihara, … - … and Biophysical Research …, 2005 - Elsevier To generate insulin-producing cells in the liver, recombinant adenovirus containing a constitutively
active mutant of PDX1 (PDX1-VP16), designed to activate target genes without the need for protein
partners, was prepared and administered intravenously to streptozotocin (STZ)-treated ... Cited by 32 - Related articles - All 4 versions
H Noguchi, M Matsushita, S Matsumoto, YF Lu, H … - … and Biophysical Research …, 2005 - Elsevier PDX-1 plays a central role in differentiation of insulin-producing cells. We previously reported
that exogenous PDX-1 protein can permeate cells and induce insulin gene expression in progenitor
cells. These data suggest a strategy for facilitating differentiation into insulin-producing ... Cited by 26 - Related articles - All 6 versions
- ►rupress.org Y Heremans, M Van De Casteele… - Journal of Cell Biology, 2002 - jcb.rupress.org Regulatory proteins have been identified in embryonic development of the endocrine
pancreas. It is unknown whether these factors can also play a role in the formation of pancreatic
endocrine cells from postnatal nonendocrine cells. The present study demonstrates that ... Cited by 52 - Related articles - BL Direct - All 8 versions
T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, Y … - … and Biophysical Research …, 2003 - Elsevier To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in inducing differentiation
into insulin-producing cells has been demonstrated in some cells and tissues. In order to carry
out efficient screening of somatic tissues and cells that can transdifferentiate into ... Cited by 46 - Related articles - All 6 versions
- ►jbc.org H Kaneto, T Matsuoka, Y Nakatani, T Miyatsuka, M … - Journal of Biological …, 2005 - ASBMB MafA, a recently isolated pancreatic -cell-specific transcription factor, is a potent activator of insulin
gene transcription. In this study, we show that MafA overexpression, together with PDX-1 (pancreatic
and duodenal homeobox factor-1) and NeuroD, markedly increases insulin gene ... Cited by 52 - Related articles - All 6 versions
- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T Matsuoka, M … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients
worldwide is increasing. The reduction of insulin biosynthesis in pancreatic β-cells is closely
associated with the onset and progression of diabetes, and thus it is important to search ... Cited by 54 - Related articles - All 6 versions
