S Del Guerra, R Lupi, L Marselli, M Masini, M Bugliani, … - Diabetes, 2005 - Am Diabetes Assoc To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the
possible mechanisms involved, we studied several functional and molecular properties of islets
isolated from the pancreata of 13 type 2 diabetic and 13 matched nondiabetic cadaveric ... Cited by 107 - Related articles - All 5 versions
M Anello, R Lupi, D Spampinato, S Piro, M Masini, U … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Little information is available on the insulin release properties of pancreatic
islets iso- lated from type 2 diabetic subjects. Since mitochondria represent the site where important
metabolites that regulate insulin secretion are generated, we studied insulin release as ... Cited by 43 - Related articles - All 3 versions
- ►endojournals.org P Marchetti, S Del Guerra, L Marselli, R Lupi, M … - Journal of Clinical …, 2004 - Endocrine Soc Several properties of pancreatic ß-cells in type 2 diabetes (T2D) were studied by using islets
isolated from T2D subjects. Moreover, because metformin has protective effects on nondiabetic
ß-cells exposed to high glucose or free fatty acid levels, we investigated its direct action ... Cited by 92 - Related articles - BL Direct - All 5 versions
CG Ostenson, H Gaisano, L Sheu, A Tibell, T Bartfai - Diabetes, 2006 - Am Diabetes Assoc Exocytosis of insulin is dependent on the soluble N-ethylmaleimide attachment protein receptor
(SNARE) complex proteins in the B-cells. We assessed insulin release as well as gene and protein
expression of SNARE complex protein in isolated pancreatic islets of type 2 diabetic ... Cited by 49 - Related articles - BL Direct - All 5 versions
S Deng, M Vatamaniuk, X Huang, N Doliba, MM Lian, A … - Diabetes, 2004 - Am Diabetes Assoc Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their pancreatic
islet cells. Whether the latter represents a primary defect or is a consequence of the former is
unknown. To examine the β-cell mass and function of islets from type 2 diabetic patients ... Cited by 96 - Related articles - BL Direct - All 4 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2
diabetes patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & M. Masini &
U. Boggi & F. Filipponi & GC Weir & DL Eizirik & M. Cnop Received ... Cited by 47 - Related articles - BL Direct - All 2 versions
- ►endojournals.org M Dubois, P Vacher, B Roger, D Huyghe, B … - Endocrinology, 2007 - Endocrine Soc Prolonged exposure of ß-cells to high glucose (glucotoxicity) diminishes insulin secretion in response
to glucose and has been linked to altered generation of metabolism-secretion coupling
factors. We have investigated whether glucotoxicity may also alter calcium handling and ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►cell.com JE Gunton, RN Kulkarni, SH Yim, T Okada, WJ … - Cell, 2005 - Elsevier Type 2 diabetes is an epidemic disease affecting almost 200 million people worldwide (Zimmet
et al., 2001). The pathogenesis involves two core defects: insulin resistance and impaired β cell
function ([Martin et al., 1992], [Weyer et al., 1999] and [DeFronzo et al., 1992]). β cell ... Cited by 115 - Related articles - All 14 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of both
Type 1 and Type 2 diabetes. This underlies the absolute or relative insu- lin insufficiency in both
conditions. In this For Debate, we consider the possible mechanisms responsible for beta- ... Cited by 123 - Related articles - BL Direct - All 6 versions
P Marchetti, S Del Prato, R Lupi, S Del Guerra - Nutrition, Metabolism and …, 2006 - Elsevier Several genes have been associated with islet cell dysfunction in Type 2 diabetes, including
those encoding for transcription factors, glucose metabolism proteins, molecules of the insulin
signaling pathways, and several others. On the other hand, many environmental factors ... Cited by 30 - Related articles - All 5 versions
