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Scholar Results 1 - 10 of about 101 related to MacDonald: Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1.... (0.14 sec) 

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat …

- diabetesjournals.org
PE MacDonald, S Obermüller, J Vikman, J … - Diabetes, 2005 - Am Diabetes Assoc
We have applied cell-attached capacitance measurements to investigate whether
synaptic-like microvesicles (SLMVs) undergo regulated exocytosis in insulinoma
and primary pancreatic β-cells. SLMV and large dense-core vesicle (LDCV) ...
Cited by 33 - Related articles - All 5 versions

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic β cells

- cell.com
PE MacDonald, M Braun, J Galvanovskis, P … - Cell Metabolism, 2006 - Elsevier
Exocytosis of secretory vesicles begins with a fusion pore connecting the
vesicle lumen to the extracellular space. This pore may then expand or it may
close to recapture the vesicle intact. The contribution of the latter, ...
Cited by 21 - Related articles - All 8 versions

Selective nucleotide-release from dense-core granules in insulin-secreting cells

- biologists.org
S Obermuller, A Lindqvist, J Karanauskaite, … - Journal of Cell Science, 2005 - jcs.biologists.org
Secretory granules of insulin-secreting cells are used to store and release
peptide hormones as well as low-molecular-weight compounds such as nucleotides.
Here we have compared the rate of exocytosis with the time courses of ...
Cited by 30 - Related articles - BL Direct - All 4 versions

Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic {beta}- …

- rupress.org
M Braun, A Wendt, B Birnir, J Broman, L … - Journal of General Physiology, 2004 - jgp.rupress.org
We have explored whether -aminobutyric acid (GABA) is released by regulated
exocytosis of GABA-containing synaptic-like microvesicles (SLMVs) in
insulin-releasing rat pancreatic ß-cells. To this end, ß-cells were ...
Cited by 49 - Related articles - BL Direct - All 5 versions

GABAB receptor activation inhibits exocytosis in rat pancreatic β-cells by G-protein- …

- nih.gov
M Braun, A Wendt, K Buschard, A Salehi, S … - The Journal of Physiology, 2004 - Physiological Soc
We have investigated the regulation of hormone secretion from rat pancreatic
islets by the GABA B receptors (GABA B Rs). Inclusion of the specific GABA B R
antagonist CGP 55845 in the extracellular medium increased ...
Cited by 22 - Related articles - All 7 versions

Temperature-sensitive random insulin granule diffusion is a prerequisite for recruiting …


R Ivarsson, S Obermuller, GA Rutter, J … - Traffic, 2004 - interscience.wiley.com
Glucose-evoked insulin secretion exhibits a biphasic time course and is
associated with accelerated intracellular granule movement. We combined live
confocal imaging of EGFP-labelled insulin granules with capacitance ...
Cited by 17 - Related articles - BL Direct - All 3 versions

Glycine, GABA and their transporters in pancreatic islets of Langerhans: evidence for a …

- biologists.org
R Gammelsaeter, M Froyland, C Aragon, NC … - Journal of cell science, 2004 - jcs.biologists.org
To elucidate the possible roles of the CNS neurotransmitters glycine and GABA in
neuroendocrine paracrine signalling, we investigated their localizations, and
those of their transport proteins, by confocal immunofluorescence and ...
Cited by 27 - Related articles - BL Direct - All 7 versions

Two-photon excitation imaging of exocytosis and endocytosis and determination of their …


H Kasai, T Kishimoto, T Nemoto, H … - Advanced drug delivery reviews, 2006 - Elsevier
Two-photon excitation imaging is the least invasive optical approach to study
living tissues. We have established two-photon extracellular polar-tracer (TEP)
imaging with which it is possible to visualize and quantify all exocytic ...
Cited by 12 - Related articles - All 5 versions

Pancreatic β-cells secrete insulin in fast-and slow-release forms

- diabetesjournals.org
DJ Michael, RA Ritzel, L Haataja, RH Chow - Diabetes, 2006 - Am Diabetes Assoc
Insulin vesicles contain a chemically rich mixture of cargo that includes ions,
small molecules, and proteins. At present, it is unclear if all components of
this cargo escape from the vesicle at the same rate or to the same extent ...
Cited by 23 - Related articles - BL Direct - All 6 versions

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion

- nih.gov
L Ma, VP Bindokas, A Kuznetsov, C Rhodes, L … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences
Confocal imaging of GFP-tagged secretory granules combined with the use of
impermeant extracellular dyes permits direct observation of insulin packaged in
secretory granules, trafficking of these granules to the plasma membrane, ...
Cited by 42 - Related articles - BL Direct - All 9 versions


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