B Raju, PE Cryer - Diabetes, 2005 - Am Diabetes Assoc The intraislet insulin hypothesis for the signaling of the glucagon secretory response to
hypoglycemia states that a decrease in arterial glucose → a decrease in β-cell insulin secretion
→ a decrease in tonic α-cell ... Cited by 60 - Related articles - All 6 versions
KM Hope, POT Tran, H Zhou, E Oseid, E Leroy, RP … - Diabetes, 2004 - Am Diabetes Assoc The “switch-off” hypothesis to explain β-cell regulation of α-cell function during
hypoglycemia has not been assessed previously in isolated islets, largely because they
characteristically do not respond ... Cited by 43 - Related articles - BL Direct - All 4 versions
H Zhou, POT Tran, S Yang, T Zhang, E LeRoy, E Oseid, … - Diabetes, 2004 - Am Diabetes Assoc The glucagon response is the first line of defense against hypoglycemia and is lost in
insulin-dependent diabetes. The ß-cell "switch-off" hypothesis proposes that a sudden cessation of
insulin secretion from ß-cells ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org NR Gosmanov, E Szoke, Z Israelian, T Smith, PE … - Diabetes Care, 2005 - Am Diabetes Assoc RESULTS—During the 2nd h of the insulin infusion, when somatostatin or saline was no longer being
infused, plasma glucose (∼2.6 mmol/l) and insulin levels (∼570 pmol/l) were comparable in both
sets of experiments (both P > 0.4). ... Cited by 27 - Related articles - All 5 versions
S Banarer, VP McGregor, PE Cryer - Diabetes, 2002 - Am Diabetes Assoc Because absence of the glucagon response to falling plasma glucose concentrations plays a key role
in the pathogenesis of iatrogenic hypoglycemia in patients with insulin-deficient diabetes and the
mechanism of this defect is ... Cited by 67 - Related articles - BL Direct - All 7 versions
[CITATION] The prevention and correction of hypoglycemia
Z Israelian, NR Gosmanov, E Szoke, M Schorr, S … - Diabetes Care, 2005 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Twelve subjects with type 2 diabetes who have been insulin requiring
were studied as a model of advanced β-cell failure. Glucagon responses were examined during a
90-min hypoglycemic clamp (∼2.8 ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►physiology.org [PDF] MA DeRosa, PE Cryer - American Journal of Physiology- …, 2004 - Am Physiological Soc 36 articles, 18 of which you can access free at: This article cites http://ajpendo.physiology.org/
cgi/content/full/287/1/E32#BIBL ... 13 other HighWire hosted articles, the first 5 are: This
article has been cited by Cited by 47 - Related articles - All 4 versions
BV Wiethop, PE Cryer - Diabetes care, 1993 - Am Diabetes Assoc OBJECTIVE--To test the hypothesis that the amino acid Ala and the beta 2-adrenergic agonist
terbutaline raise plasma glucose concentrations substantially, and do so through different
mechanisms, in IDDM patients. ... Cited by 17 - Related articles - BL Direct - All 5 versions
