CD Filippo, R Marfella, S Cuzzocrea, E Piegari, P … - Diabetes, 2005 - Am Diabetes Assoc This study investigated the role of heme oxygenase (HO)-1 in the cardiac tissue injury of acute
ischemia/reperfusion (I/R) in diabetic streptozotocin (STZ)-induced hyperglycemic rats. The effects
of 1) hemin, an inducer of HO expression and activity, and 2) zinc protoporphyrin IX ... Cited by 42 - Related articles - All 5 versions
X Liu, J Wei, DH Peng, MD Layne, SF Yet - Diabetes, 2005 - Am Diabetes Assoc Increased production of reactive oxygen species contributes to the etiology of diabetes
complications. Pathophysiological stimuli that increase oxidative stress upregulate heme oxygenase
(HO)-1, a cytoprotective heme–degrading enzyme. We hypothesized that HO-1 may be ... Cited by 44 - Related articles - All 6 versions
- ►physiology.org NG Abraham, R Rezzani, L Rodella, A … - American Journal of …, 2004 - Am Physiological Soc Heme oxygenase (HO)-1 represents a key defense mechanism against oxidative injury. Hyperglycemia
produces oxidative stress and various perturbations of cell physiology. The effect of streptozotocin
(STZ)-induced diabetes on aortic HO activity, heme content, the number of circulating ... Cited by 59 - Related articles - All 4 versions
- ►diabetesjournals.org R Marfella, C Di Filippo, K Esposito, F Nappo, E Piegari … - Diabetes, 2004 - Am Diabetes Assoc We investigated the role of inducible nitric oxide synthase (iNOS) on ischemic myocardial damage
and angiogenic process in genetically deficient iNOS (iNOS −/− ) mice and wild-type littermates
(iNOS +/+ ), with and without streptozotocin-induced (70 mg/kg intravenously) diabetes. ... Cited by 39 - Related articles - BL Direct - All 4 versions
L Rodella, BD Lamon, R Rezzani, B Sangras, AI … - Free Radical Biology and …, 2006 - Elsevier Hyperglycemia has been linked to increased oxidative stress, a resultant endothelial cell
dysfunction, and, ultimately, apoptosis. Heme oxygenases (HO-1/HO-2) and the products of their
activity, biliverdin/bilirubin and carbon monoxide (CO), play a physiological role in the ... Cited by 30 - Related articles - All 5 versions
S Rossi, MD Amico, A Capuano, M Romano, P … - Mediators of …, 2006 - hindawi.com Page 1. Hindawi Publishing Corporation Mediators of Inflammation Volume 2006,
Article ID 60285, Pages 1–6 DOI 10.1155/MI/2006/60285 Research Communication
Hyperglycemia in Streptozotocin-Induced Diabetes Leads to ... Cited by 2 - Related articles - View as HTML - BL Direct - All 11 versions
S Quan, PM Kaminski, L Yang, T Morita, M Inaba, S … - … and Biophysical Research …, 2004 - Elsevier Heme oxygenase-1 (HO-1) represents a key defense mechanism against oxidative injury. Hyperglycemia
has been linked to increased oxidative stress, leading to endothelial dysfunction, delayed cell
replication, and enhanced apoptosis. The effect of streptozotocin (STZ)-induced diabetes ... Cited by 48 - Related articles - All 4 versions
K Takeda, J Lin, S Okubo, S Akazawa-Kudoh, K … - Journal of molecular and …, 2004 - Elsevier Transient glucose deprivation (TGD) has been shown to induce a resistance to a subsequent
ischemia and reperfusion injury in the heart. Induction of cyclooxygenase-2 (COX-2) and heme
oxygenase-1 (HO-1) is known to mediate the powerful defensive adaptation of the heart ... Cited by 15 - Related articles - All 5 versions
