KV Ramana, B Friedrich, R Tammali, MB West, A … - Diabetes, 2005 - Am Diabetes Assoc Activation of protein kinase C (PKC) has been linked to the development of secondary diabetes
complications. However, the underlying molecular mechanisms remain unclear. We examined
the contribution of aldose reductase, which catalyzes the first, and the rate-limiting, step of ... Cited by 47 - Related articles - All 5 versions
KV Ramana, B Friedrich, S Srivastava, A Bhatnagar, … - Diabetes, 2004 - Am Diabetes Assoc Activation of the polyol pathway has been linked to the development of secondary diabetic
complications. However, the underlying molecular mechanisms remain unclear. To probe the
contribution of this pathway, we examined whether inhibition of aldose reductase, which ... Cited by 61 - Related articles - BL Direct - All 4 versions
KV Ramana, D Chandra, S Srivastava, A Bhatnagar … - Journal of Biological …, 2002 - ASBMB Abnormal vascular smooth muscle cell (VSMC) proliferation is a key feature of atherosclerosis
and restenosis; however, the mechanisms regulating growth remain unclear. Herein we show
that inhibition of the aldehyde-metabolizing enzyme aldose reductase (AR) inhibits NF- B ... Cited by 82 - Related articles - BL Direct - All 4 versions
KV Ramana, A Bhatnagar, S Srivastava, UC Yadav, … - Journal of Biological …, 2006 - ASBMB Products of lipid peroxidation such as 4-hydroxy-trans-2-nonenal (HNE) trigger multiple signaling
cascades that variably affect cell growth, differentiation, and apoptosis. Because glutathiolation
is a significant metabolic fate of these aldehydes, we tested the possibility that the ... Cited by 37 - Related articles - BL Direct - All 7 versions
- ►endojournals.org SK Srivastava, KV Ramana, A Bhatnagar - Endocrine reviews, 2005 - Endocrine Soc Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The reduction of
glucose by the AR-catalyzed polyol pathway has been linked to the development of secondary
diabetic complications. Although treatment with AR inhibitors has been shown to prevent ... Cited by 97 - Related articles - All 6 versions
- ►fasebj.org KV RAMANA, A BHATNAGAR, SK SRIVASTAVA - The FASEB Journal, 2004 - FASEB Increased expression of adhesion molecules by the activated endothelium is a critical feature
of vascular inflammation associated with several disease states such as atherosclerosis.
However, mechanisms regulating the endothelial induction of adhesion molecules are ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org S Srivastava, KV Ramana, R Tammali, SK Srivastava, … - Diabetes, 2006 - Am Diabetes Assoc The objective of this study was to determine whether the polyol pathway enzyme aldose reductase
mediates diabetes abnormalities in vascular smooth muscle cell (SMC) growth. Aldose reductase
inhibitors (tolrestat or sorbinil) or antisense aldose reductase mRNA prevented ... Cited by 18 - Related articles - BL Direct - All 7 versions
- ►jbc.org KV Ramana, AA Fadl, R Tammali, A Reddy, AK … - Journal of Biological …, 2006 - ASBMB Abnormal production of inflammatory cytokines and chemokines is a key feature of bacterial
endotoxin, lipopolysaccharide (LPS)-induced inflammation, and cytotoxicity; however, the mechanisms
regulating production of inflammatory markers remain unclear. Herein, we show that ... Cited by 18 - Related articles - All 7 versions
KV Ramana, BL Dixit, S Srivastava, GK Balendiran, SK … - Biochemistry, 2000 - pubs.acs.org Because you do not have JavaScript enabled, the Quick Search functionality is not displayed
here. Please enable JavaScript or use the Advanced Search Page. ... Supported in part by National
Institutes of Health Grants DK36118, HL55477, and HL59378. ... University of Louisville ... Cited by 38 - Related articles - BL Direct - All 3 versions
KV Ramana, A Bhatnagar, SK Srivastava - FEBS letters, 2004 - Elsevier In this study, we examined the role of aldose reductase (AR) in regulating the cytotoxic effects
of TNF-α on human umbilical vein endothelial cells. Inhibition of AR by sorbinil or tolrestat prevented
TNF-α-induced increase in Bax and Bak and the downregulation of Bcl-2. Inhibition of AR ... Cited by 25 - Related articles - All 5 versions
