K Shibuya, K Kanasaki, M Isono, H Sato, M Omata, T … - Diabetes, 2005 - Am Diabetes Assoc We have previously reported that N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), which is a
tetrapeptide hydrolyzed by ACE, inhibits the transforming growth factor-β (TGF-β)-induced expression
of extracellular matrix proteins via inhibition of the Smad signaling in human mesangial ... Cited by 25 - Related articles - All 6 versions
S Rasoul, OA Carretero, H Peng, MA Cavasin, J … - Journal of …, 2004 - journals.lww.com Objective: N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a potent natural inhibitor of hematopoietic
stem cell proliferation which is degraded mainly by angiotensin-converting enzyme (ACE). In
vitro, Ac-SDKP inhibits collagen production by cardiac fibroblasts; while in vivo it blocks ... Cited by 42 - Related articles - BL Direct - All 6 versions
HW Kim, BC Kim, CY Song, JH Kim, HK Hong, HS Lee - Kidney international, 2004 - nature.com In the present study, we examined whether decreased expression of the TGF- type II receptor
(TGF- IIR) in TGF- IIR gene heterozygous (TGF- IIR +/- ) (HT) mice could inhibit the Smad signaling
pathway and subsequent progression of renal lesions when streptozotocin (STZ) ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org S Pokharel, PP van Geel, UC Sharma, JPM Cleutjens, … - Circulation, 2004 - Am Heart Assoc From Experimental and Molecular Cardiology, Cardiovascular Research Institute Maastricht
(CARIM) (SP, UCS, HJGMC, YMP), and the Department of Pathology (JPMC), University Hospital
Maastricht, Maastricht, and the Department of Cardiology, University Hospital Groningen, ... Cited by 43 - Related articles - BL Direct - All 7 versions
- ►asnjournals.org M Omata, H Taniguchi, D Koya, K Kanasaki, R … - Journal of the American …, 2006 - Am Soc Nephrol N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), which is hydrolyzed by angiotensin-converting
enzyme, is a natural regulator of hematopoiesis. Here it is shown that Ac-SDKP inhibits TGF-
action in mesangial cells. Because TGF- is thought to play a pivotal role in the ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org F Yang, XP Yang, YH Liu, J Xu, O Cingolani, NE … - Hypertension, 2004 - Am Heart Assoc Inflammation may play an important role in the pathogenesis of cardiac fibrosis in heart failure
(HF) after myocardial infarction (MI). N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a naturally
occurring antifibrotic peptide whose plasma concentration is increased 4- to 5-fold by ... Cited by 62 - Related articles - BL Direct - All 8 versions
N Iwamoto, HJ Xano, T Yoshioka, H Shiraga, K Nitta, T … - Life Sciences, 2000 - Elsevier A natural tetrapeptide, acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is a physiological negative
regulator of hematopoiesis. The precursor of AcSDKP, thymocin β4, is expressed in many tissues
including kidney. The present study examined the antiproliferative effect of AcSDKP in ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org MA Cavasin, NE Rhaleb, XP Yang, OA Carretero - Hypertension, 2004 - Am Heart Assoc N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a ubiquitous tetrapeptide hydrolyzed almost
exclusively by angiotensin-converting enzyme (ACE). Chronic treatment with Ac-SDKP decreases
cardiac and renal fibrosis and inflammatory cell infiltration in hypertensive rats. However, ... Cited by 34 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org NE Rhaleb, H Peng, P Harding, M Tayeh, MC LaPointe … - Hypertension, 2001 - Am Heart Assoc N-Acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural inhibitor of pluripotent hematopoietic
stem cell entry into the S phase of the cell cycle and is normally present in human plasma.
Ac-SDKP is exclusively hydrolyzed by ACE, and its plasma concentration is increased ... Cited by 64 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org M Azizi, E Ezan, L Nicolet, JM Grognet, J Menard - Hypertension, 1997 - Am Heart Assoc Abstract The acute administration of the angiotensin-converting enzyme (ACE) inhibitor captopril
to healthy subjects transiently increases 5.5-fold the plasma levels of a natural stem-cell
regulator, N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP). The aim of this study was to ... Cited by 67 - Related articles - BL Direct - All 4 versions
