- ►diabetesjournals.org TC Sandeep, R Andrew, NZM Homer, RC … - Diabetes, 2005 - Am Diabetes Assoc 11ß-Hydroxysteroid dehydrogenase type 1 (11HSD1) regenerates cortisol from
cortisone within adipose tissue and liver. 11HSD1 inhibitors may enhance insulin
sensitivity in type 2 diabetes and be most efficacious in obesity when ... Cited by 66 - Related articles - All 8 versions
- ►shouxi.net R Andrew, J Westerbacka, J Wahren, H Yki- … - Diabetes, 2005 - Am Diabetes Assoc Cortisol is regenerated from cortisone by 11β-hydroxysteroid dehydrogenase type
1 (11HSD1), amplifying glucocorticoid action in adipose tissue and liver. 11HSD1
inhibitors are being developed for type 2 diabetes and may be most ... Cited by 54 - Related articles - All 6 versions
- ►endojournals.org R Andrew, K Smith, GC Jones, BR Walker - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc We have investigated the use of [9,11,12,12- 2 H 4 ]cortisol (d4F) to
distinguish the dehydrogenase and reductase activities. On metabolism by
dehydrogenation, d4F loses 11 - deuterium, forming trideuterated cortisone ... Cited by 43 - Related articles - BL Direct - All 6 versions
- ►endojournals.org DJ Wake, NZM Homer, R Andrew, BR Walker - Journal of Clinical Endocrinology & Metabolism, 2006 - Endocrine Soc Context: Extraadrenal regeneration of cortisol by 11ß-hydroxysteroid
dehydrogenase type 1 (11HSD1) is increased after a mixed meal. It is unknown
which tissue is responsible and whether this reflects the complex ... Cited by 20 - Related articles - BL Direct - All 6 versions
- ►endojournals.org JW Tomlinson, B Sinha, I Bujalska, M … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Central obesity is associated with increased morbidity and mortality.
Preadipocyte proliferation and differentiation contribute to increases in
adipose tissue mass, yet the mechanisms that underlie these processes ... Cited by 125 - Related articles - BL Direct - All 6 versions
- ►endojournals.org RC Andrews, O Rooyackers, BR Walker - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Six diet-controlled nonobese diabetic patients with hemoglobin A 1c less than
8%, and six matched controls participated in a double-blind, cross-over
comparison of carbenoxolone (100 mg every 8 h, orally, for 7 d) and ... Cited by 117 - Related articles - BL Direct - All 10 versions
- ►endojournals.org RS Lindsay, DJ Wake, S Nair, J Bunt, DEW … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Metabolic effects of cortisol may be critically modulated by glucocorticoid
metabolism in tissues. Specifically, active cortisol is regenerated from
inactive cortisone by the enzyme 11ß-hydroxysteroid dehydrogenase type 1 ... Cited by 114 - Related articles - BL Direct - All 6 versions
S Engeli, J Böhnke, M Feldpausch, K … - Obesity, 2004 - nature.com Results: The 11 -HSD1 gene was highly expressed in human adipose tissue. 11
-HSD2 mRNA was also detectable at lower levels. Adipose 11 -HSD1 gene expression
was increased by two-fold and was positively correlated with waist ... Cited by 96 - Related articles - BL Direct - All 5 versions
S Nair, YH Lee, RS Lindsay, BR Walker, PA … - Diabetologia, 2004 - Springer Aims/hypothesis. The enzyme 11β-hydroxysteroid de- hydrogenase type 1
(11β-HSD1) modulates tissue- specific glucocorticoid concentrations by
generating active cortisol. We have shown that adipose tissue 11β-HSD1 ... Cited by 46 - Related articles - BL Direct - All 5 versions
