- ►diabetesjournals.org G Boden, C Homko, M Mozzoli, LC Showe, C … - Diabetes, 2005 - Am Diabetes Assoc Thiazolidinediones (TZDs) are a new class of insulin-sensitizing drugs. To
explore how and in which tissues they improve insulin action, we obtained fat
and muscle biopsies from eight patients with type 2 diabetes before and 2 ... Cited by 53 - Related articles - All 5 versions
G Boden, P Cheung, M Mozzoli, SK Fried - Metabolism, 2003 - Elsevier The current study aimed to compare the effects of treatment (2 months) with
thiazolidinediones (TZDs) and placebo on glucose and fat metabolism in patients
with type 2 diabetes (T2DM) in a crossover design. Eight patients received ... Cited by 70 - Related articles - All 10 versions
M Laplante, WT Festuccia, G Soucy, Y … - Diabetes, 2006 - Am Diabetes Assoc In this study, we aimed to establish the mechanisms whereby peroxisome
proliferator–activated receptor γ (PPARγ) agonism brings about
redistribution of fat toward subcutaneous depots and away from visceral ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►endojournals.org J Rieusset, J Seydoux, SI Anghel, P Escher, … - Molecular Endocrinology, 2004 - Endocrine Soc The peroxisome proliferator-activated receptor (PPAR ) plays a major role in fat
tissue development and physiology. Mutations in the gene encoding this receptor
have been associated to disorders in lipid metabolism. A thorough ... Cited by 18 - Related articles - BL Direct - All 3 versions
- ►nih.gov L Wilson-Fritch, S Nicoloro, M Chouinard, MA … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Adipose tissue plays a central role in the control of energy homeostasis through
the storage and turnover of triglycerides and through the secretion of factors
that affect satiety and fuel utilization. Agents that enhance insulin ... Cited by 152 - Related articles - BL Direct - All 15 versions
I Bogacka, H Xie, GA Bray, SR Smith - Diabetes, 2005 - Am Diabetes Assoc Thiazolidenediones such as pioglitazone improve insulin sensitivity in diabetic
patients by several mechanisms, including increased uptake and metabolism of
free fatty acids in adipose tissue. The purpose of the present study was to ... Cited by 122 - Related articles - All 5 versions
G Yang, L Li, Y Tang, G Boden - Biochemical and Biophysical Research …, 2006 - Elsevier We have evaluated the effects of a 2 week treatment with pioglitazone (Pio, 4
mg/kg.d) on hepatic and peripheral insulin sensitivity, plasma adiponectin, and
resistin concentrations in lipid-infused rats. Lipid infusion caused a ... Cited by 16 - Related articles - All 5 versions
- ►nih.gov SZ Duan, CY Ivashchenko, SE Whitesall, LG D' … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig 1 Department of Molecular and Integrative Physiology and 2 Department of
Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA. 3
Department of Surgery, William Beaumont Hospital, Royal Oak, Michigan, USA. ... Cited by 38 - Related articles - BL Direct - All 9 versions
T Allen, F Zhang, SA Moodie, LE Clemens, A … - Diabetes, 2006 - Am Diabetes Assoc Halofenate has been shown previously to lower triglycerides in dyslipidemic
subjects. In addition, significant decreases in fasting plasma glucose were
observed but only in type 2 diabetic patients. We hypothesized that ... Cited by 38 - Related articles - BL Direct - All 9 versions
V Simha, A Garg - Current opinion in lipidology, 2006 - journals.lww.com Recent findings: Marked hypertriglyceridemia and reduced levels of high-density
lipoprotein cholesterol are commonly seen, and the severity of these metabolic
abnormalities seems to be related to the extent of fat loss. The precise ... Cited by 43 - Related articles - BL Direct - All 5 versions
