W Zheng, JX She - Diabetes, 2005 - Am Diabetes Assoc The lymphoid-specific phosphatase (LYP) encoded by PTPN22 is involved in preventing spontaneous
T-cell activation by dephosphorylating and inactivating T-cell receptor-associated Csk
kinase. We have genotyped 396 type 1 diabetic patients and 1,178 control subjects of ... Cited by 63 - Related articles - All 5 versions
- ►bmj.com H Qu, MC Tessier, TJ Hudson, C Polychronakos - British Medical Journal, 2005 - jmg.bmj.com This paper leaves two potential questions unanswered. Firstly, results of case–control studies
are potentially artefacts of population stratification, no matter how well matched are the two
groups. Secondly, although Bottini et al show that the T allele encodes a protein unable to ... Cited by 45 - Related articles - All 6 versions
- ►pasteur.ac.ir [PDF] MB Ladner, N Bottini, AM Valdes, JA Noble - Human immunology, 2005 - Elsevier The PTPN22 (protein tyrosine phosphatase N22) gene encodes the protein tyrosine phosphatase
Lyp. One function of Lyp is downregulation of T-cell signaling through its interaction with the
negative regulatory kinase C-terminal Src tyrosine kinase (Csk). A single nucleotide ... Cited by 72 - Related articles - All 4 versions
A Zhernakova, P Eerligh, C Wijmenga, P Barrera, BO … - Genes and Immunity, 2005 - nature.com Protein tyrosine phosphatase PTPN22 is involved in the negative regulation of T-cell
responsiveness. Recently, the association of a coding variant of the PTPN22
gene-R620W(1858C>T) with a number of autoimmune diseases has been described. ... Cited by 52 - Related articles - BL Direct - All 4 versions
A Skorka, T Bednarczuk, E Bar-Andziak, J … - Clinical …, 2005 - interscience.wiley.com Objective Susceptibility to Graves' disease (GD) is to a significant extent determined by genetic
factors of which the best known are those associated with the HLA and the CTLA4 locus.
Recently, two studies on British Caucasians reported that a single nucleotide ... Cited by 45 - Related articles - All 4 versions
S Onengut-Gumuscu, KG Ewens, RS Spielman, P … - Genes and immunity, 2004 - nature.com Type I diabetes (T1D) is a complex disorder, which arises from the autoimmune destruction of
the insulin-secreting cells of the pancreas leading to a life-long dependence on exogenous
insulin. A recent study of T1D cases and controls provided evidence for association ... Cited by 70 - Related articles - All 2 versions
- ►eje-online.org H Kahles, E Ramos-Lopez, B Lange, O Zwermann, M … - European Journal of …, 2005 - EFES Results: Our study confirms a significant association between allelic variation of the PTPN22
1858 C/T polymorphism and type 1 diabetes mellitus (T1D). 1858T was observed more frequently
in T1D patients (19.3% vs 11.3%, P = 0.0009; odds ratio for allele T = 1.88, 95% ... Cited by 31 - Related articles - BL Direct - All 7 versions
- ►nih.gov AB Begovich, SJ Caillier, HC Alexander, JM Penko, … - The American Journal of …, 2005 - Elsevier We recently reported the association of the minor allele of a missense SNP (1858C→T [dbSNP
accession number rs2476601]) in the gene for hematopoietic-specific intracellular protein tyrosine
phosphatase (PTPN22) with susceptibility to both rheumatoid arthritis (RA [MIM 180300]) ( ... Cited by 73 - Related articles - All 7 versions
D Smyth, JD Cooper, JE Collins, JM Heward, JA … - Diabetes, 2004 - Am Diabetes Assoc In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive
irrefutable linkage and association results have been rare to date. Recently, it has been reported
that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding ... Cited by 244 - Related articles - BL Direct - All 5 versions
MK Viken, SS Amundsen, TK Kvien, KM Boberg, IM … - Genes and immunity, 2005 - nature.com A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene, encoding a tyrosine
phosphatase, has been reported to be associated with type I diabetes and some other autoimmune
diseases. To further investigate whether this polymorphism may be a general ... Cited by 69 - Related articles - All 3 versions
