- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of
diabetic patients worldwide is increasing. The reduction of insulin biosynthesis
in pancreatic β-cells is closely associated with the onset and progression ... Cited by 51 - Related articles - All 6 versions
J Imai, H Katagiri, T Yamada, Y Ishigaki, T … - Biochemical and Biophysical Research …, 2005 - Elsevier To generate insulin-producing cells in the liver, recombinant adenovirus
containing a constitutively active mutant of PDX1 (PDX1-VP16), designed to
activate target genes without the need for protein partners, was prepared ... Cited by 32 - Related articles - All 4 versions
- ►jbc.org H Kaneto, T Matsuoka, Y Nakatani, T … - Journal of Biological Chemistry, 2005 - ASBMB MafA, a recently isolated pancreatic -cell-specific transcription factor, is a
potent activator of insulin gene transcription. In this study, we show that MafA
overexpression, together with PDX-1 (pancreatic and duodenal homeobox ... Cited by 50 - Related articles - All 6 versions
T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, … - Biochemical and Biophysical Research …, 2003 - Elsevier To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in
inducing differentiation into insulin-producing cells has been demonstrated in
some cells and tissues. In order to carry out efficient screening of ... Cited by 46 - Related articles - All 6 versions
- ►diabetesjournals.org LZ Cao, DQ Tang, ME Horb, SW Li, LJ Yang - Diabetes, 2004 - Am Diabetes Assoc Pdx1 has been shown to convert hepatocytes into both exocrine and endocrine
pancreatic cells in mice, but it fails to selectively convert hepatocytes into
pure insulin-producing cells (IPCs). The molecular mechanisms underlying ... Cited by 65 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org AM Holland, LJ Góñez, G Naselli, RJ … - Diabetes, 2005 - Am Diabetes Assoc The homeodomain transcription factor Pdx1 is essential for pancreas development.
To investigate the role of Pdx1 in the adult pancreas, we employed a mouse model
in which transcription of Pdx1 could be reversibly repressed by ... Cited by 38 - Related articles - BL Direct - All 5 versions
H Kojima, M Fujimiya, K Matsumura, P … - Nature medicine, 2003 - nature.com To explore induced islet neogenesis in the liver as a strategy for the treatment
of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the
pancreatic duodenal homeobox-1 gene (Ipf1; also known as Pdx-1) to ... Cited by 232 - Related articles - BL Direct - All 3 versions
I Ber, K Shternhall, S Perl, Z Ohanuna, I … - Journal of Biological Chemistry, 2003 - ASBMB Pancreatic and duodenal homeobox gene-1 (PDX-1) regulates pancreas development
during embryogenesis, whereas in the adult it controls β-cell function. Here we
analyze whether PDX-1 functions as a pancreatic differentiation factor and ... Cited by 104 - Related articles - BL Direct - All 4 versions
- ►montreal-diabetes-research-center.org [PDF] ME Horb, CN Shen, D Tosh, JMW Slack - Current Biology, 2003 - Elsevier Results: We show that a modified form of Pdx1, carrying the VP16 transcriptional
activation domain, can cause conversion of liver to pancreas, both in vivo and
in vitro. Transgenic Xenopus tadpoles carrying the construct ... Cited by 177 - Related articles - All 17 versions
H Taniguchi, E Yamato, F Tashiro, H Ikegami, … - Gene Therapy, 2003 - nature.com -cell neogenesis is expected to provide a new therapy for diabetes. Numerous
studies have demonstrated that transcriptional regulation involving pdx-1 is
essential for endocrine neogenesis in vivo and in vitro. Therefore, it is ... Cited by 56 - Related articles - BL Direct - All 4 versions
