- ►shouxi.net EE Kershaw, NM Morton, H Dhillon, L Ramage, … - Diabetes, 2005 - Am Diabetes Assoc Local glucocorticoid (GC) action depends on intracellular GC metabolism by
11β-hydroxysteroid dehydrogenases (11βHSDs). 11βHSD1 activates GCs, while
11βHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through ... Cited by 82 - Related articles - All 6 versions
G GCs - kershawlab.pitt.edu Local glucocorticoid (GC) action depends on intracellu- lar GC metabolism by 11
-hydroxysteroid dehydroge- nases (11 HSDs). 11 HSD1 activates GCs, while 11 HSD2
inactivates GCs. Adipocyte-specific amplifica- tion of GCs through ... Related articles - View as HTML
- ►endojournals.org K Kannisto, KH Pietilainen, E Ehrenborg, A … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) catalyzes the
interconversion of inactive cortisone to active cortisol. Overexpression of
11ß-HSD-1 in murine adipose tissue results in glucocorticoid receptor (GR) ... Cited by 104 - Related articles - BL Direct - All 7 versions
- ►nih.gov JM Paterson, NM Morton, C Fievet, CJ Kenyon, … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences In obese humans and rodents there is increased expression of the key
glucocorticoid (GC) regenerating enzyme, 11β-hydroxysteroid dehydrogenase type
1 (11β-HSD1), in adipose tissue. This increased expression appears to be ... Cited by 144 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org NM Morton, JM Paterson, H Masuzaki, MC … - Diabetes, 2004 - Am Diabetes Assoc The metabolic syndrome (visceral obesity, insulin resistance, type 2 diabetes,
and dyslipidemia) resembles Cushing's Syndrome, but without elevated circulating
glucocorticoid levels. An emerging concept suggests that the aberrantly ... Cited by 191 - Related articles - BL Direct - All 4 versions
- ►rupress.org A Hermanowski-Vosatka, JM Balkovec, K Cheng … - Journal of Experimental Medicine, 2005 - jem.rupress.org The enzyme 11ß–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive
cortisone into active cortisol in cells, thereby raising the effective
glucocorticoid (GC) tone above serum levels. We report that pharmacologic ... Cited by 121 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org TC Sandeep, R Andrew, NZM Homer, RC … - Diabetes, 2005 - Am Diabetes Assoc 11ß-Hydroxysteroid dehydrogenase type 1 (11HSD1) regenerates cortisol from
cortisone within adipose tissue and liver. 11HSD1 inhibitors may enhance insulin
sensitivity in type 2 diabetes and be most efficacious in obesity when ... Cited by 66 - Related articles - All 8 versions
- ►nih.gov H Masuzaki, H Yamamoto, CJ Kenyon, JK … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Obesity is closely associated with the metabolic syndrome, a combination of
disorders including insulin resistance, diabetes, dyslipidemia, and
hypertension. A role for local glucocorticoid reamplification in obesity ... Cited by 215 - Related articles - BL Direct - All 6 versions
- ►endojournals.org JW Tomlinson, B Sinha, I Bujalska, M … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Central obesity is associated with increased morbidity and mortality.
Preadipocyte proliferation and differentiation contribute to increases in
adipose tissue mass, yet the mechanisms that underlie these processes ... Cited by 125 - Related articles - BL Direct - All 6 versions
- ►endojournals.org E Rask, BR Walker, S Soderberg, DEW … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Cushing's syndrome and the metabolic syndrome share clinical similarities.
Reports of alterations in the hypothalamic-pituitary-adrenal (HPA) axis are
inconsistent, however, in the metabolic syndrome. Recent data highlight the ... Cited by 212 - Related articles - BL Direct - All 6 versions
