D Lundsgaard, TL Holm, L Hornum, H Markholst - Diabetes, 2005 - Am Diabetes Assoc To understand the ability of regulatory T-cells to control diabetes development in clinically relevant
situations, we established a new model of accelerated diabetes in young DP-BB rats by transferring
purified T-cells from DR-BB rats made acutely diabetic. Transfer of 3, 5, 10, or 23 million ... Cited by 30 - Related articles - All 5 versions
- ►jimmunol.org P Poussier, T Ning, T Murphy, D Dabrowski, … - The Journal of …, 2005 - Am Assoc Immnol One of the BB rat diabetes (diabetes mellitus (DM)) susceptibility genes is an Ian5 mutation resulting
in premature apoptosis of naive T cells. Impaired differentiation of regulatory T cells has been
suggested as one possible mechanism through which this mutation contributes to ... Cited by 32 - Related articles - All 5 versions
- ►diabetesjournals.org EP Blankenhorn, L Rodemich, C Martin-Fernandez, J … - Diabetes, 2005 - Am Diabetes Assoc BBDR rats develop autoimmune diabetes only after challenge with environmental
perturbants. These perturbants include polyinosinic:polycytidylic acid (poly I:C, a ligand of
toll-like receptor 3), agents that deplete regulatory T-cell (Treg) populations, and a non–β- ... Cited by 12 - Related articles - All 6 versions
- ►jimmunol.org D Zipris, JL Hillebrands, RM Welsh, J Rozing … - The Journal of …, 2003 - Am Assoc Immnol Viruses are believed to contribute to the pathogenesis of autoimmune type 1A diabetes in
humans. This pathogenic process can be modeled in the BBDR rat, which develops pancreatic
insulitis and type 1A-like diabetes after infection with Kilham's rat virus (RV). The ... Cited by 32 - Related articles - BL Direct - All 6 versions
[CITATION] Impaired post-thymic development of regulatory CD4 25 T cells contributes to …
- ►jimmunol.org II Mendez, YH Chung, HS Jun, JW Yoon - The Journal of Immunology, 2004 - Am Assoc Immnol Macrophages play a critical role in the pathogenesis of Kilham rat virus (KRV)-induced autoimmune
diabetes in diabetes-resistant BioBreeding (DR-BB) rats. This investigation was initiated to determine
the role of macrophage-derived soluble mediators, particularly NO, in the pathogenesis of ... Cited by 9 - Related articles - BL Direct - All 4 versions
JP Mordes, DL Guberski, JH Leif, BA Woda, JF … - Diabetes, 2005 - Am Diabetes Assoc We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility
complex congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1 u/u/a ) occurs with
a cumulative frequency of ∼2% at a median age of 59 days. The disease is characterized ... Cited by 10 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org JL Hillebrands, B Whalen, JTJ Visser, J … - The Journal of …, 2006 - Am Assoc Immnol Biobreeding (BB) rats model type 1 autoimmune diabetes (T1D). BB diabetes-prone (BBDP)
rats develop T1D spontaneously. BB diabetes-resistant (BBDR) rats develop T1D after immunological
perturbations that include regulatory T cell (Treg) depletion plus administration of low ... Cited by 13 - Related articles - BL Direct - All 6 versions
M Honeyman - Current opinion in immunology, 2005 - Elsevier Viruses associated with type 1 diabetes have eluded definition as causal, with the exception
of rubella virus. False-negative results may have occurred due to the focus on subjects at symptomatic
onset, who may be heterogeneous and differently affected by viruses. In addition, assays ... Cited by 17 - Related articles - All 3 versions
[CITATION] In vivo control of diabetogenic T-cells by regulatory CD41CD251 T-cells …
