S Ullrich, S Berchtold, F Ranta, G Seebohm, G Henke, … - Diabetes, 2005 - Am Diabetes Assoc Glucocorticoid excess predisposes to the development of diabetes, at least in part through impairment
of insulin secretion. The underlying mechanism has remained elusive. We show here that dexamethasone
upregulates transcription and expression of the serum- and glucocorticoid-inducible ... Cited by 50 - Related articles - All 5 versions
- ►physiology.org F Grahammer, G Henke, C Sandu, R … - American Journal of …, 2006 - Am Physiological Soc In vitro experiments have revealed the ability of serum- and glucocorticoid-inducible kinase 1
(SGK1) to stimulate intestinal Na + -coupled glucose cotransporter 1 (SGLT1) and intestinal Na
+ /H + exchanger 3 (NHE3). The present study explored the contribution of SGK1 to the ... Cited by 22 - Related articles - BL Direct - All 4 versions
KM Boini, AM Hennige, DY Huang, B Friedrich, M … - Diabetes, 2006 - Am Diabetes Assoc Excess salt intake decreases peripheral glucose uptake, thus impairing glucose tolerance. Stimulation
of cellular glucose uptake involves phosphatidylinositide-3-kinase (PI-3K)–dependent activation
of protein kinase B/Akt. A further kinase downstream of PI-3K is serum- and glucocorticoid- ... Cited by 13 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Palmada, C Boehmer, A Akel, J Rajamanickam, S … - Diabetes, 2006 - Am Diabetes Assoc Phosphatidylinositol 3-kinase (PI3 kinase) inhibition disrupts the ability of insulin to stimulate
GLUT1 and GLUT4 translocation into the cell membrane and thus glucose transport. The effect
on GLUT4 but not on GLUT1 is mediated by activation of protein kinase B (PKB). The ... Cited by 24 - Related articles - BL Direct - All 5 versions
B Davani, N Portwood, G Bryzgalova, MK Reimer, T … - Diabetes, 2004 - Am Diabetes Assoc Glucocorticoids are diabetogenic hormones because they decrease glucose uptake, increase
hepatic glucose production, and inhibit insulin release. To study the long-term effects of increased
glucocorticoid sensitivity in β-cells, we studied transgenic mice overexpressing the rat ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org F Ranta, D Avram, S Berchtold, M Düfer, G Drews, F … - Diabetes, 2006 - Am Diabetes Assoc Glucocorticoid excess induces hyperglycemia, which may result in diabetes. The present experiments
explored whether glucocorticoids trigger apoptosis in insulin-secreting cells. Treatment of mouse
β-cells or INS-1 cells with the glucocorticoid dexamethasone (0.1 μmol/l) over 4 days in ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] C Lambillotte, P Gilon, JC Henquin - Journal of Clinical …, 1997 - pubmedcentral.nih.gov The direct effects of glucocorticoids on pancreatic cell function were studied with normal mouse
islets. Dexa- methasone inhibited insulin secretion from cultured islets in a concentration-dependent
manner: maximum of 75% at 250 nM and IC50 at 20 nM dexamethasone. This inhibi- tion ... Cited by 130 - Related articles - BL Direct - All 9 versions
IK Jeong, SH Oh, BJ Kim, JH Chung, YK Min, MS … - Diabetes research and …, 2001 - Elsevier Complex results concerning the effect of glucocorticoids on insulin secretion have been
reported. The aim of this study is to clarify the direct effects of glucocorticoids on pancreatic islets
and to determine whether the effect of glucocorticoids on insulin biosynthesis or release ... Cited by 19 - Related articles - All 5 versions
S Ullrich, Y Zhang, D Avram, F Ranta, D Kuhl, HU … - … and Biophysical Research …, 2007 - Elsevier Glucocorticoids blunt insulin release, an effect partially due to activation of Kv channels. Similar
to those channels Na + /K + ATPase activity repolarizes the plasma membrane. The present
study explored whether glucocorticoids increase the Na + /K + ATPase activity in ... Cited by 10 - Related articles - All 5 versions
R Baltaev, N Strutz-Seebohm, G Korniychuk, S … - Pflügers Archiv European …, 2005 - Springer Abstract The human cardiac transient outward potas- sium current I to is formed by co-assembly
of voltage- dependent K + channel (Kv 4.3) pore-forming a-subun- its with differently spliced
K channel interacting protein (KChIP) accessory proteins. I to is of considerable ... Cited by 12 - Related articles - All 3 versions
