RA Heptulla, LM Rodriguez, L Bomgaars, MW … - Diabetes, 2005 - Am Diabetes Assoc Postprandial hyperglycemia and preprandial hypoglycemia contribute to poor glycemic control
in type 1 diabetes. We hypothesized that postprandial glycemic excursions could be normalized
in type 1 diabetes by suppressing glucagon with pramlintide acetate in the immediate ... Cited by 35 - Related articles - All 10 versions
LM RODRIGUEZ, KJ MASON, MW HAYMOND, RA … - Pediatric …, 2007 - journals.lww.com ABSTRACT: Pramlintide, a synthetic analog of amylin, improves postprandial
hyperglycemia. We compared subcutaneous (sc) pram- lintide injection with square wave pramlintide
infusion in adolescents with type 1 diabetes (T1DM). Eight subjects with T1DM underwent ... Cited by 11 - Related articles - BL Direct - All 8 versions
GS Jeha, RA Heptulla - Pediatric Diabetes, 2006 - interscience.wiley.com Abstract: Recent studies in adult patients with type 1 diabetes mellitus (T1DM) and T2DM have
examined the potential utility, benefits, and side effects of agents that augment insulin secretion
after oral ingestion of nutrients in comparison with intravenous nutrient delivery, the so- ... Cited by 7 - Related articles - BL Direct - All 3 versions
EL Kleppinger, EM Vivian - The Annals of pharmacotherapy, 2003 - Harvey Whitney Books DATA SYNTHESIS: Clinical trials have demonstrated that amylin in combination with insulin
controls postprandial glucose levels by decreasing food intake, slowing gastric emptying, and
suppressing glucagon secretion. Clinical trials also showed significant decreases in ... Cited by 20 - Related articles - BL Direct - All 4 versions
M Fineman, C Weyer, DG Maggs, S Strobel, … - Hormone and …, 2002 - thieme-connect.com Aims: Amylin is a second beta-cell hormone that is normally co-secreted with insulin in response
to meals; it complements the effects of insulin in postprandial glucose control, in part by suppressing
glucagon secretion. In patients with type 2 diabetes, mealtime administration of the ... Cited by 92 - Related articles - BL Direct - All 10 versions
S Edelman, S Garg, J Frias, D Maggs, Y Wang, B … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—Baseline A1C was 8.1% for both groups and at week 29 had decreased comparably
(pramlintide −0.5% [95% CI −0.61 to −0.33]; placebo −0.5% [−0.63 to −0.35]). Pramlintide treatment
significantly reduced postprandial glucose excursions (incremental area under the curve [ ... Cited by 39 - Related articles - BL Direct - All 10 versions
F Whitehouse, DF Kruger, M Fineman, L Shen, JA … - Diabetes Care, 2002 - Am Diabetes Assoc RESULTS—Treatment with pramlintide led to a mean reduction in HbA 1c of 0.67% from baseline
to week 13 that was significantly (P < 0.0001) greater than the placebo reduction (0.16%), and
a significant placebo-corrected treatment difference was sustained through week 52 (P = ... Cited by 136 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org C Weyer, A Gottlieb, DD Kim, K Lutz, S Schwartz, M … - Diabetes Care, 2003 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—In this randomized, single-blind,
placebo-controlled, five-way crossover study, 19 subjects with type 1 diabetes using regular
insulin and 21 subjects with type 1 diabetes using insulin lispro underwent five ... Cited by 58 - Related articles - BL Direct - All 7 versions
- ►endojournals.org J Dupre, MT Behme, TJ McDonald - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Exendin-4 is a reptilian peptide that activates the mammalian receptor for truncated
glucagon-like peptide 1 (tGLP-1) with relatively prolonged actions. Exendin-4 and tGLP-1 can
reduce blood glucose levels by stimulating insulin secretion, inhibiting glucagon ... Cited by 48 - Related articles - All 4 versions
HP Chase, K Lutz, R Pencek, B Zhang, L Porter - The Journal of Pediatrics, 2009 - Elsevier In 9 evaluable subjects, plasma pramlintide concentrations increased dose-proportionately; mean
peak plasma concentration (C max ) (15-μg dose, 93 ± 9 pg/mL; 30-μg dose, 202 ± 21
pg/mL) occurred 0.3 h (median time to peak concentration) after administration. ... Cited by 2 - Related articles - All 18 versions
