- ►diabetesjournals.org A Gallo, G Ceolotto, P Pinton, E Iori, E Murphy, GA … - Diabetes, 2005 - Am Diabetes Assoc Hyperglycemia determines the vascular complications of diabetes through different
mechanisms: one of these is excessive activation of the isoform ß2 of protein kinase C
(PKC-ß2). Metformin, a widely used antidiabetic agent, is associated with decreased ... Cited by 34 - Related articles - All 6 versions
H Khouri, F Collin, D Bonnefont-Rousselot … - European Journal of …, 2004 - interscience.wiley.com Metformin (1,1-dimethylbiguanide) is an antihyperglycaemic drug used to normalize glucose
concentrations in type 2 diabetes. Furthermore, antioxidant benefits have been reported in diabetic
patients treated with metformin. This work was aimed at studying the scavenging capacity ... Cited by 11 - Related articles - BL Direct - All 4 versions
N Ouslimani, J Peynet, D Bonnefont-Rousselot, P … - Metabolism, 2005 - Elsevier Beyond its antidiabetic activity justifying its use in the treatment of the type 2 diabetes, metformin
(MET [dimethylguanidine, Glucophage]) has been shown to exhibit antioxidant properties in
vitro, which could contribute to limit the deleterious vascular complications of diabetes. ... Cited by 28 - Related articles - All 13 versions
- ►ahajournals.org K Isoda, JL Young, A Zirlik, LA MacFarlane, N … - … , and vascular biology, 2006 - Am Heart Assoc Methods and Results— Metformin dose-dependently inhibited IL-1ß–induced release of the
pro-inflammatory cytokines IL-6 and IL-8 in ECs, SMCs, and M s. Investigation of potential signaling
pathways demonstrated that metformin diminished IL-1ß–induced activation and nuclear ... Cited by 43 - Related articles - All 8 versions
M Mahrouf, N Ouslimani, J Peynet, R Djelidi, M … - Biochemical …, 2006 - Elsevier Oxidative stress plays a major role in the pathogenesis and in the onset of macrovascular complications
of diabetes. We previously reported that the antihyperglycaemic drug metformin was able to decrease
significantly intracellular reactive oxygen species (ROS) production of bovine aortic ... Cited by 18 - Related articles - All 4 versions
JB Majithiya, R Balaraman - Life Sciences, 2006 - Elsevier Metformin treatment reduced blood pressure without having any significant effect on blood glucose
level in STZ-diabetic rats. Enhanced phenylephrine (PE)-induced contraction and impaired acetylcholine
(Ach)-induced relaxation in STZ-diabetic rats were restored to normal by metformin ... Cited by 21 - Related articles - All 3 versions
D Bonnefont-Rousselot, B Raji, S Walrand, M Gard [ … - Metabolism, 2003 - Elsevier Metformin (dimethylbiguanide) is an antihyperglycemic agent used in type 2 diabetes. Beyond
its action on glycemic control, metformin exhibits other intrinsic effects that could play a role in
prevention against diabetes complications. Some studies thus reported an improvement ... Cited by 51 - Related articles - BL Direct - All 7 versions
D Pavlovic, R Kocic, G Kocic, T Jevtovic, S … - Diabetes, Obesity and …, 2000 - ingentaconnect.com 1 Biochemistry Institute, Medical Faculty of NisÆ, NisÆ, Yugoslavia 2 Endocrinology Clinic, Medical
Faculty of NisÆ, NisÆ, Yugoslavia 3 Endocrinology Institute, Medical Faculty of Belgrade,
Belgrade, Yugoslavia ... The principal metabolic effect of metforminąan oral ... Cited by 51 - Related articles - BL Direct - All 3 versions
N Ouslimani, M Mahrouf, J Peynet, D Bonnefont- … - Metabolism, 2007 - Elsevier Beyond its antihyperglycemic action, the antidiabetic oral drug metformin possesses antioxidant
properties that may contribute to improve the cardiovascular deleterious effects of the diabetic
disease. We explored whether metformin could modulate the redox-sensible expression ... Cited by 17 - Related articles - All 9 versions
C Wilcock, ND Wyre, CJ Bailey - The Journal of pharmacy and …, 1991 - ncbi.nlm.nih.gov The subcellular localization of metformin was studied in livers of 18 h fasted rats treated orally
with [14C]metformin 20 microCi kg-1, 50 mg kg-1. Sequential determination of 14C radioactivity
showed that maximum concentrations of metformin in plasma (about 15 mumol L-1) and ... Cited by 23 - Related articles - All 2 versions
