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Scholar Results 1 - 10 of about 101 related to Stalker: The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. (0.10 sec) 

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 …


TJ Stalker, Y Gong, R Scalia - Diabetes, 2005 - Am Diabetes Assoc
Cardiovascular complications are the leading cause of morbidity and mortality in diabetic
patients. Endothelial dysfunction with impaired endothelial nitric oxide (NO) synthase
(eNOS) activity is a widely accepted cause of diabetic vasculopathy. The mechanisms of ...
Cited by 29 - Related articles - All 5 versions

A novel role for calpains in the endothelial dysfunction of hyperglycemia

- fasebj.org [PDF] 
TJ Stalker, CB Skvarka, R Scalia - The FASEB Journal, 2003 - FASEB
Page 1. The FASEB Journal express article 10.1096/fj.02-1213fje. Published online
June 3, 2003. A novel role for calpains in the endothelial dysfunction of hyperglycemia
Timothy J. Stalker, Christopher B. Skvarka, and Rosario Scalia ...
Cited by 39 - Related articles - BL Direct - All 4 versions

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by …


M Averna, R Stifanese, R De Tullio, F Salamino, M … - FEBS …, 2007 - interscience.wiley.com
Ca 2+ loading of Jurkat and bovine aorta endothelium cells induces the degradation of the neuronal
and endothelial nitric oxide synthases that are selectively expressed in these cell lines. For neuronal
nitric oxide synthase, this process involves a conservative limited proteolysis without ...
Cited by 9 - Related articles - BL Direct - All 4 versions

Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of …

- fasebj.org [PDF] 
Y Dong, J Tan, MZ Cui, G Zhao, G Mao, N Singh, X Xu - The FASEB Journal, 2005 - FASEB
The FASEB Journal express article 10.1096/fj.05-4524fje. Published online December 14,
2005. ... Calpain inhibitor MDL28170 modulates Aβ formation by ... Yunzhou Dong,* Jianxin
Tan,* Mei-Zhen Cui,* Guojun Zhao,* Guozhang Mao,* Neena Singh, † and Xuemin Xu*
Cited by 10 - Related articles - BL Direct - All 3 versions

In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 ( …


M Averna, R Stifanese, R De Tullio, F Salamino, … - FEBS …, 2008 - interscience.wiley.com
We have shown previously that isolated heat shock protein 90 (HSP90) and nitric oxide synthase
(NOS), once associated in a heterocomplex, become completely resistant to calpain
digestion. In this study, it is shown that, in vivo, under conditions of calpain activation, the ...
Cited by 4 - Related articles - BL Direct - All 2 versions

Somatostatin increases glucocorticoid binding and signaling in macrophages by …


A Bellocq, S Doublier, S Suberville, J Perez, B … - Journal of Biological …, 1999 - ASBMB
Somatostatin has direct anti-inflammatory actions and participates in the anti-inflammatory actions
of glucocorticoids, but the mechanisms underlying this regulation remain poorly understood.
The objective of this study was to evaluate whether somatostatin increases glucocorticoid ...
Cited by 32 - Related articles - BL Direct - All 3 versions

Characterization of the calpain/calpastatin system in human hemopoietic cell lines


R Stifanese, M Averna, F Salamino, C Cantoni, MC … - Archives of Biochemistry …, 2006 - Elsevier
As previously suggested by PCR analysis [R. DeTullio, R. Stifanese, F. Salamino, S.
Pontremoli, E. Melloni, Characterization of a new p94-like calpain form in human
lymphocytes, Biochem. J. 375 (2003) 689–696], a p94-like calpain was now established ...
Cited by 7 - Related articles - All 4 versions

Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary …

- physiology.org
Y Su, ER Block - American Journal of Physiology- Lung Cellular …, 2000 - Am Physiological Soc
Pulmonary artery endothelial cells (PAEC) were exposed to normoxia or hypoxia (0% O 2
-95% N 2 -5% CO 2 ) in the presence and absence of calpain inhibitor I or calpeptin, after which
endothelial nitric oxide synthase (eNOS) activity and protein content were assayed. ...
Cited by 55 - Related articles - BL Direct - All 3 versions

Cariporide inhibits high glucose-mediated adhesion of monocyte–endothelial cell …


SX Wang, XY Sun, XH Zhang, SX Chen, YH Liu, LY Liu - Life sciences, 2006 - Elsevier
The aim of this study was to examine whether cariporide, a new inhibitor of Na + /H + exchanger
1 (NHE-1), may inhibit high glucose-induced monocyte–endothelial cell adhesion and the expression
of intercellular adhesion molecule-1 (ICAM-1). Cultured endothelial cells were incubated ...
Cited by 8 - Related articles - All 4 versions

The calpain inhibitor, A-705253, corrects penile nitrergic nerve dysfunction in …


MR Nangle, MA Cotter, NE Cameron - European journal of pharmacology, 2006 - Elsevier
Calpains, a superfamily of Ca 2+ -activated proteases, are associated with an array of physiological
and pathological events, including susceptibility to diabetes. Recently, increased calpain activity
has been linked to reduced endothelium-derived nitric oxide-mediated vasodilatation in ...
Cited by 8 - Related articles - All 5 versions


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