- ►diabetesjournals.org K Silver, M Tolea, J Wang, TI Pollin, F Yao, BD … - Diabetes, 2005 - Am Diabetes Assoc In vitro and in vivo studies suggest a role for betacellulin in islet neogenesis
and regeneration. Since abnormalities in β-cell function play a role in the
development of type 2 diabetes, a mutation in the betacellulin gene could ... Cited by 14 - Related articles - All 5 versions
T Nakagawa, H Furuta, T Sanke, S … - Diabetes research and clinical practice, 2005 - Elsevier Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, is an
important factor in the growth and/or differentiation of pancreatic β cells. In
this point of view, we determined the transcriptional start site of the ... Cited by 5 - Related articles - All 10 versions
SC Elbein, X Wang, MA Karim, WS Chu, KD … - BMC Medical Genetics, 2006 - biomedcentral.com Betacellulin is a member of the epidermal growth factor family, expressed at the
highest levels predominantly in the pancreas and thought to be involved in islet
neogenesis and regeneration. Nonsynonymous coding variants were reported to ... Cited by 4 - Related articles - Cached - All 9 versions
- ►diabetesjournals.org Y Nakano, H Furuta, A Doi, S Matsuno, T … - Diabetes, 2005 - Am Diabetes Assoc Betacellulin (BTC) plays an important role in differentiation, growth, and
antiapoptosis of pancreatic β-cells. We characterized about 2.3 kb of the
5′-flanking region of human BTC gene and identified six polymorphisms (− ... Cited by 1 - Related articles - BL Direct - All 5 versions
KD Silver, VL Magnuson, M Tolea, J Wang, … - Journal of Molecular Medicine, 2006 - Springer Page 1. J Mol Med (2006) 84: 616–623 DOI 10.1007/s00109-006-0052-6 ORIGINAL ARTICLE
Kristi D. Silver . Victoria L. Magnuson . Magdalena Tolea . Jian Wang . ... Cited by 1 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org L Li, Z Yi, M Seno, I Kojima - Diabetes, 2004 - Am Diabetes Assoc Activin A and betacellulin (BTC) are thought to regulate differentiation of
pancreatic ß-cells during development and regeneration of ß-cells in adults.
In the present study, we used neonatal rats treated with streptozotocin ... Cited by 60 - Related articles - BL Direct - All 6 versions
- ►endojournals.org T Ogata, AJ Dunbar, Y Yamamoto, Y Tanaka, … - Endocrinology, 2005 - Endocrine Soc We previously described a novel alternatively spliced mRNA transcript of the
betacellulin (BTC) gene. This splice isoform, termed BTC- 4, lacks the C-loop of
the epidermal growth factor motif and the transmembrane domain as a result ... Cited by 11 - Related articles - BL Direct - All 6 versions
- ►endojournals.org L Li, M Seno, H Yamada, I Kojima - Endocrinology, 2001 - Endocrine Soc Betacellulin is thought to promote growth and differentiation of pancreatic
ß-cells. We investigated the effect of betacellulin on regeneration of
pancreatic ß-cells in 90%-pancreatectomized rats. Ninety percent ... Cited by 50 - Related articles - BL Direct - All 3 versions
Y Yamamoto, S Yamada, T Kodera, A Hara, K … - Growth Factors, 2008 - informahealthcare.com Previous studies have shown the efficacy of betacellulin (BTC) to promote
β-cell regeneration. Because of its short half-life, however, the effect of BTC
may have been underestimated. This study was conducted to assess the effect ... Related articles - All 6 versions
CJ Gallagher, CJ Gordon, CD Langefeld, JC … - Molecular Genetics and Metabolism, 2006 - Elsevier African Americans (AA) are at increased risk for developing type 2 diabetes
mellitus (T2DM) relative to European Americans. We previously detected linkage
of T2DM to 6q24-q27 (LOD 2.26) at 163.5 cM, closest to marker D6S1035, in a ... Cited by 8 - Related articles - All 3 versions
