- ►diabetesjournals.org DM Lehman, DJ Fu, AB Freeman, KJ Hunt, RJ Leach, T … - Diabetes, 2005 - Am Diabetes Assoc Excess O-glycosylation of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) may be involved
in the pathogenesis of type 2 diabetes. The enzyme O-GlcNAc–selective N-acetyl-β-d glucosaminidase
(O-GlcNAcase) encoded by MGEA5 on 10q24.1-q24.3 reverses this modification by ... Cited by 43 - Related articles - All 5 versions
- ►jbc.org C Toleman, AJ Paterson, TR Whisenhunt, JE … - Journal of Biological …, 2004 - ASBMB Histones and transcription factors are regulated by a number of post-translational modifications
that in turn regulate the transcriptional activity of genes. These modifications occur in large, multisubunit
complexes. We have reported previously that mSin3A can recruit O-GlcNAc transferase ( ... Cited by 59 - Related articles - All 5 versions
- ►nih.gov JA Hanover, ME Forsythe, PT Hennessey … - Proceedings of the …, 2005 - National Acad Sciences O-linked N-acetylglucosamine (O-GlcNAc) is an evolutionarily conserved modification of nuclear
pore proteins, signaling kinases, and transcription factors. The O-GlcNAc transferase (OGT) catalyzing
O-GlcNAc addition is essential in mammals and mediates the last step in a ... Cited by 45 - Related articles - BL Direct - All 8 versions
ME Forsythe, DC Love, BD Lazarus, EJ … - Proceedings of the …, 2006 - National Acad Sciences A dynamic cycle of O-linked N-acetylglucosamine (O-GlcNAc) addition and removal acts on nuclear
pore proteins, transcription factors, and kinases to modulate cellular signaling cascades. Two
highly conserved enzymes (O-GlcNAc transferase and O-GlcNAcase) catalyze the final ... Cited by 19 - Related articles - BL Direct - All 9 versions
G Parker, R Taylor, D Jones, D McClain - Journal of Biological Chemistry, 2004 - ASBMB Glycogen synthase is post-translationally modified by both phosphate and O-linked N-acetylglucosamine
(O-GlcNAc). In 3T3-L1 adipocytes exposed to high concentrations of glucose, O-GlcNAc contributes
to insulin resistance of glycogen synthase. We sought to determine whether O-GlcNAc ... Cited by 34 - Related articles - BL Direct - All 4 versions
L Wells, Y Gao, JA Mahoney, K Vosseller, C Chen, … - Journal of Biological …, 2002 - ASBMB Multiple nucleocytoplasmic proteins, including transcription factors, cytoskeletal proteins,
oncogenes, and kinases, are post-translationally modified with β-N-acetylglucosamine
(O-GlcNAc) 1 (1-3). In each case studied, the glycan has a turnover rate that is much ... Cited by 107 - Related articles - BL Direct - All 6 versions
C Toleman, AJ Paterson, JE Kudlow - BBA-General Subjects, 2006 - Elsevier NCOAT is a bifunctional nucleo-cytoplasmic protein with both O-GlcNAcase and histone acetyltransferase
domains. The O-GlcNAcase domain catalyzes the removal of O-linked GlcNAc modifications
from proteins and we have found that it resides in the N-terminal third of NCOAT. The ... Cited by 8 - Related articles - All 4 versions
- ►jbc.org GJ Parker, KC Lund, RP Taylor, DA McClain - Journal of Biological Chemistry, 2003 - ASBMB We have investigated the mechanism by which high concentrations of glucose inhibit insulin
stimulation of glycogen synthase. In NIH-3T3-L1 adipocytes cultured in low glucose (LG; 2.5
mM), the half-maximal activation concentration (A 0.5 ) of glucose 6-phosphate was 162 ± ... Cited by 88 - Related articles - BL Direct - All 5 versions
D Heckel, N Comtesse, N Brass, N Blin, KD … - Human Molecular …, 1998 - Oxford Univ Press By screening a meningioma expression library with autologous serum we identified four cDNA
clones representing a novel gene with striking homology to Caenorhabditis elegans hyaluronidase
as indicated by BLASTP analysis. In humans hyaluronidase has been implicated in ... Cited by 65 - Related articles - BL Direct - All 4 versions
SY Park, J Ryu, W Lee - Exp Mol Med, 2005 - e-emm.or.kr 1From the Department of Biochemistry College of Medicine, Dongguk University Gyeongju
780-714, Korea 2Biophysics Laboratory Veteran Affairs Medical Center Department of Physiology
and Biophysics School of Medicine, State University of New York at Buffalo Buffalo, NY ... Cited by 35 - Related articles - View as HTML - All 13 versions
