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Association of the Diabetes Gene Calpain-10 With Subclinical Atherosclerosis

- shouxi.net
MO Goodarzi, KD Taylor, X Guo, MJ Quiñones, J Cui, Y … - Diabetes, 2005 - Am Diabetes Assoc
The powerful relation between atherosclerosis and diabetes may have a common genetic
basis. However, few genes predisposing to both have been identified. Calpain-10 (CAPN10)
was the first gene for type 2 diabetes identified by positional cloning, wherein a ...
Cited by 15 - Related articles - All 5 versions

Genetic determinants of diabetes and atherosclerosis


BD Mitchell, IG Imumorin - Current Atherosclerosis Reports, 2002 - Springer
Introduction Coronary heart disease (CHD) is the leading cause of death in developed
countries, and in patients with type 2 diabetes the risk of CHD mortality is increased two- to fourfold
[1]. The risk of myocardial infarction and CHD mortality is as high in diabetic patients ...
Cited by 9 - Related articles - BL Direct - All 2 versions

Association of protein tyrosine phosphatase-N1 polymorphisms with coronary …


KP Burdon, JL Bento, CD Langefeld, JK Campbell, JJ … - Diabetes, 2006 - Am Diabetes Assoc
Individuals with type 2 diabetes are at increased risk of cardiovascular disease (CVD) mortality
and display increased levels of subclinical CVD. Genetic variation in PTPN1, a diabetes susceptibility
gene, was investigated for a role in diabetic atherosclerosis. The PTPN1 gene encodes ...
Cited by 13 - Related articles - BL Direct - All 5 versions

Vascular smooth muscle cell spreading onto fibrinogen is regulated by calpains …


F Paulhe, A Bogyo, H Chap, B Perret, C Racaud- … - … and Biophysical Research …, 2001 - Elsevier
Fibrinogen deposition and smooth muscle cell migration are important causes of atherosclerosis
and angiogenesis. Involvement of calpains in vascular smooth muscle cell adhesion onto fibrinogen
was investigated. Using calpain inhibitors, we showed that activation of calpains was ...
Cited by 19 - Related articles - BL Direct - All 5 versions

Genetic links between diabetes mellitus and coronary atherosclerosis


JM Ordovas - Current Atherosclerosis Reports, 2007 - Springer
Diabetes mellitus is one of the most common endo- crine disorders. It affects almost 6% of the
world's population, and its prevalence continues to increase. The causes of diabetes mellitus
are multifactorial, and in the general population both genetic and environ- mental factors ...
Cited by 3 - Related articles - BL Direct - All 6 versions

[CITATION] Microvascular permeability in inflammation


V Huxley, RE Rumbaut - Physiology of Inflammation
Cited by 3 - Related articles

Calpains: a physiological regulator of the endothelial barrier?

- physiology.org
V Gonscherowski, BF Becker, L Moroder, … - American Journal of …, 2006 - Am Physiological Soc
The intracellular protease calpain, abundant in endothelial cells (EC), is assumed to be inactive
under physiological conditions but may account for Ca 2+ -linked pathophysiological events.
However, nonstimulated EC contained autolyzed, activated calpain. Adding 12–48 µM ...
Cited by 4 - Related articles - All 3 versions

[PDF] Albumin escape from microvessels in kidney, heart and skeletal muscle in …


MWB BRADBURY - Experimental physiology, 1991 - expphysiol.highwire.org
Experimental Physiology (1991), 76, 899-904 Printed in Great Britain ... HEART AND SKELETAL
MUSCLE IN EXPERIMENTAL DIABETES MELLITUS IN THE ANAESTHETIZED RAT ... GG
PINTER*, SL LIGHTMANt, PD WILSONt, L. YUENt AND MWB BRADBURY§ * Department ...
Cited by 5 - Related articles - All 8 versions

[CITATION] Type 2 diabetes mellitus


SC Elbein, KC Chiu, MA … - OXFORD …, 2002 - OXFORD UNIVERSITY PRESS
Cited by 6 - Related articles - BL Direct

Replication of calpain-10 genetic association with carotid intima-media thickness


MO Goodarzi, KD Taylor, MR Jones, B Fang, X Guo, … - Atherosclerosis, 2009 - Elsevier
Diabetes and atherosclerosis may share common genetic determinants. A prior study in Hispanics
found association of haplotypes in the diabetes gene calpain-10 (CAPN10) with carotid artery
intima-media thickness (CIMT). This study sought to replicate this association in an ...
Related articles - All 39 versions


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